PREVENTIVE ONCOLOGY ACADEMIC AWARDS

这项研究的重点是多发性骨髓瘤，一种B细胞恶性肿瘤。职业生涯 目标是扩大对B细胞瘤的认识，包括非霍奇金瘤 淋巴瘤(NHL)，并利用实验室科学培训来研究 暴露的分子标记。获得培训和经验 需要成为一个独立的调查员，重点放在这些领域， 计划的目标是： 1.斯坦福大学开设的审计免疫学和分子流行病学课程 大学； 2.撰写一篇关于NHL亚型流行病学的综述文章； 3.使用现有的计算机化数据来调查人口统计 NHL亚型的发生以及吸烟和HIV感染在NHL中的作用 NHL；以及， 4.写一篇方法论文章，概述设计权衡，以尽量减少 实验室流行病学研究中的信息偏差 测量。 在Kaiser Permanente进行研究的一个主要优势来自 患者的长期随访。有关物理信息的预期信息 并且可以从医学图像中快速地获取医学特征 唱片。建议利用这一优势，收集 评估两个假设的原始数据： 5.就年龄而言，8至18岁女孩的身高相对较高 与随后的上皮性乳腺癌风险有关联吗？ 6.隐睾症(固定术)的外科矫正术 相对年轻的年龄将生殖细胞睾丸癌的风险降低到 比以后进行修正的程度更大吗？

The research has focused on multiple myeloma, a B-cell malignancy. Career goals are to expand knowledge of B-cell neoplasia to include non-Hodgkin's lymphoma (NHL) and to use training in laboratory science to study molecular markers of exposure. To obtain the training and experience needed to become an independent investigator with emphasis in these areas, it is planned to: 1. Audit Immunology and Molecular Epidemiology courses at Stanford University; 2. Write a review article on the epidemiology of NHL subtypes; 3. Use existing computerized data to investigate the demographic occurrence of NHL subtypes, and the role of smoking and HIV infection in NHL; and, 4. Write a methodological article outlining design trade-offs to minimize information bias in epidemiologic research using laboratory-based measurements. A major strength of conducting research at Kaiser Permanente stems from the long-term follow-up of patients. Prospective information on physical and medical characteristics can be quickly obtained from the medical record. It is proposed to take advantage of this strength and collect original data to evaluate two hypotheses: 5. Is relatively tall height-for-age in girls aged 8 to 18 years associated with the subsequent risk of epithelial breast cancer? 6. Does surgical correction of cryptorchidism (orchidopexy) at a relatively young age reduce the risk of germ-cell testicular cancer to a greater extent than if the correction is made later?