Epidemiology of Marginal Zone Lymphoma

描述(由申请人提供)： 非霍奇金淋巴瘤分类的显著改进为研究一种常见的亚型--边缘带淋巴瘤(MZL)的病因、预防和病程创造了难得的机会。我们建议(1)病例对照研究和(2)设置在KP人群中的病例系列。我们将在1996年至2003年6月期间诊断的金伯利进程成员中确定250例MZL病例。将从一般金伯利进程人群中随机抽样作为对照组，以达到1：1的病例对照比。将从病历和计算机数据库中获得信息。具体目标如下： 1.我们将探讨慢性感染性和炎症性疾病史增加MZL风险的假设。 2.我们将获得试点数据，以评估(A)病理诊断的质量和(B)病例和对照中既往病史的患病率，以便将来进行大规模的流行病学研究。 3.在这些病例中，我们将描述MZL的病程和处理，以确定预后的特征和未来临床研究的领域。 这项研究的主要优点是以人口为基础的背景和对MZL的关注。此外，该图表是关于医疗暴露、病程和疾病管理的预期信息的高度准确和完整的来源。预计75%的病例将在诊断前在健康计划中有10年或更长时间的登记，并在医疗记录中相应地提供完整的信息。这项拟议的研究将探索重要的假设，提供开展大规模研究所需的先导数据，确定预后因素，为患者和提供者提供他们做出生活方式和治疗决策所需的关键信息，并检查护理方面的变化，以专注于未来的临床研究。

DESCRIPTION (provided by applicant): Dramatic improvements in the classification of non-Hodgkin's lymphoma create an exceptional opportunity to investigate the causes, prevention, and course of a common subtype, marginal zone lymphoma (MZL). We propose (1) a case-control study and (2) a case series set in the KP population. We will identify 250 cases of MZL among KP members diagnosed during the period 1996 through June, 2003. A random sample of the general KP population will be identified as a control group to achieve a case-control ratio of 1:1. Information from the medical record and computerized databases will be obtained. The specific aims are as follows: 1. We will explore hypotheses that a history of chronic infectious and inflammatory diseases increases the risk of MZL. 2. We will obtain pilot data to assess (a) the quality of the pathologic diagnosis and (b) the prevalence of past medical history in cases and controls for a future, large-scale epidemiologic study. 3. Among the cases, we will describe the course and management of MZL to characterize prognosis and identify areas for future clinical research. The key strengths of the study are the population-based setting and the focus on MZL. In addition, the chart is a highly accurate and complete source of prospective information on medical exposures, disease course, and disease management. It is anticipated that 75% of the cases will have 10 years or longer enrollment in the health plan preceding their diagnosis, with correspondingly complete information in the medical record. The proposed study will explore important hypotheses, provide pilot data needed to develop a large-scale study, identify prognostic factors to give patients and providers the crucial information they need to make lifestyle and treatment decisions, and examine variation in care to focus future clinical research.