Motion-adaptive PET technology for brain imaging of freely moving mice

该项目旨在开发新的脑成像技术，以适应和纠正响应灵敏、自由移动的鼠标的运动。目前的技术要求受试者处于无意识状态，这就排除了使用成像技术来研究认知和行为任务中由外部刺激激活的信号通路。通过利用新的辐射探测器、运动跟踪和计算技术，该项目希望弥合这一技术差距，并在该领域提供重大的技术和概念进步。这将提供重要的好处，例如为神经科学家提供新的工具，以回答有关哺乳动物大脑如何调节行为适应不断变化的环境的基本问题。

This project aims to develop new brain imaging technology that adapts to and corrects for the motion of a responsive, freely moving mouse. Current technology requires the subject to be unconscious, precluding the use of imaging to study signalling pathways activated by external stimuli during cognitive and behavioural tasks. By harnessing new radiation detector, motion tracking and computational technologies, the project expects to bridge this technology gap and provide significant technical and conceptual advances in the field. This will provide important benefits, such as equipping neuroscientists with new tools to answer fundamental questions about how the mammalian brain regulates behavioural adaptation to a changing environment.