SOLUABLE POLYMER SUPPORTS FOR ORGANIC SYNTHESIS

描述：聚合物支持的化学经历了戏剧性的复兴。 主要的推动力是“小分子”的发展。 药物发现的组合技术。然而，尽管 交联型聚苯乙烯等树脂的流行和成功， 不溶性聚合物在有机材料中的使用有许多缺点 综合。这可能会对反应速度产生不利影响， 选择性和产量。光谱分析也受到了阻碍。 此外，固体载体在水中不是特别有效。 因此，许多目前有价值的生物催化转化不能 要有效率地执行。可溶的支撑位将允许预期 和传统溶液化学的方法，同时提供 聚合物相的好处。 调查人员已经开始了一个多方面的计划，以开发 可溶性聚合物在有机合成中的应用。这包括 发现用于合成应用的独特的可溶聚合物。 值得注意的是，一种被称为“平行聚合物合成”的方法将提供 获得了大量的新奇材料。最后，示例如下 突出了可溶技术在合成中的力量 复杂的分子，如前列腺素和手性积木。这 将包括图书馆的建设和聚合物的实施- 一种被称为“振荡液体相”的支撑技术 我们新共聚聚合物的物理性质的变化。它是 预计可溶性聚合物载体将获得越来越多的用途 在接下来的几年里进行合成。

DESCRIPTION: Polymer-supported chemistry has undergone a dramatic revival. The primary impetus has been the development of "small-molecule" combinatorial technology for drug discover. However, despite the popularity and successes of resins such as cross-linked polystyrene, insoluble polymers have a number of drawbacks for use in organic synthesis. There can be detrimental effects on reaction rates, selectivities and yields. and spectroscopic analyses are hampered. Furthermore, solid supports are not particularly effective in water. Hence, a number of currently valuable biocatalytic transformations can not be efficiently performed. A soluble support would allow the expectations and methods of traditional solution chemistry, while affording the benefits of the polymer phase. The investigators have embarked on a multifaceted program to develop the utility of soluble polymers in organic synthesis. This includes the discovery of unique soluble polymers for synthetic applications. Significantly a method coined "parallel polymer synthesis" will provide access to a large number of novel materials. Finally, examples are presented that highlight the power of soluble technology in the synthesis of complex molecules such as prostanoids and chiral building blocks. This will include library construction and the implementation of a polymer- supported technique termed the "oscillating liquid phase" made possible by the variance in physical properties of our new co-polymers. It is anticipated that soluble-polymer supports will finding increasing utility in synthesis in the coming years.