SUBCUTANEOUS FAT, BLOOD LIPIDS AND SUBSEQUENT OUTCOME

本提案是为了继续对以下问题进行长期连续研究 体脂水平及其分布和危险因素 心血管疾病。衡量身体肥胖的方法包括人体测量， 水下称重和双能X射线吸收测量法。风险 导致心血管疾病的因素包括血压、胆固醇、 甘油三酯，高密度脂蛋白和低密度脂蛋白，载脂蛋白， 空腹血糖、胰岛素和某些荷尔蒙。重要的新系列 数据将从800多名青少年和成人参与者中收集 FELS纵向研究扩展系列记录和收集 其他变量。来自这项独特研究的新的和现有的数据， 它始于1929年，将用于更好地了解脂肪 以及正常个体的脂肪分布。它还将允许 确定哪些因素与辅助因素有关， 使儿童和/或成年人容易受到高水平身体的影响 肥胖，并发展为高水平的身体肥胖和 心血管疾病。 这个项目有三组具体目标： 1)研究儿童和成年期间身体的一系列变化 心血管疾病的构成、脂肪相关变量和危险因素 并研究这些变化模式之间的联系 变量， 2)检查身体成分、脂肪组织之间的关系 心血管疾病的分布危险因素和生活方式 变量，以及 3)开发、实施和验证身体研究的新方法 组成。

The present proposal is for continuation of a long-term serial study of levels of body fatness and its distribution as well as risk factors for cardiovascular disease. Measures of body fatness include anthropometry, underwater weighing, and dual energy X-ray absorptiometry. The risk factors for cardiovascular disease include blood pressure, cholesterol, triglycerides, high and low density lipoproteins, apolipoproteins, fasting glucose, insulin, and certain hormones. Important new serial data will be collected from over 800 juvenile and adult participants in the Fels Longitudinal Study to extend the serial records and collect additional variables. New and existing data from this unique study, which began in 1929, will be used to allow a better understanding of fat and fat-distribution in normal individuals. It will also allow a determination of which factors, in association with co-factors, predispose individuals as children and/or adults to high levels of body fatness, and to develop high levels of body fatness and risk for cardiovascular disease. There are three groups of specific aims for this project: 1) to study serial changes during childhood and adulthood in body composition, fat-related variables, and risk factors for cardiovascular disease and to study associations among patterns of change in these variables, 2) to examine associations among body composition, adipose tissue distribution risk factors for cardiovascular disease, and lifestyle variables, and 3) to develop, implement, and validate new methods for the study of body composition.