SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT)

项目4将重点关注以下患者的局部灌注模式： 阿尔茨海默型痴呆（AD）。 一百二十五 AD可疑病例（CDR = 0.5）和40例正常对照（CDR = 0.）将 至少要跟踪三年。 预计各国 大约2/3的可疑病例（n = 80）将被归类为 随访结束时AD。 这将允许检查 SPECT测量的可疑患者之间的脑灌注差异 随访时诊断为AD的病例和 没有 将采用各种统计技术来评估 SPECT灌注模式的视觉和定量。 这些 技术也将允许评估MRI之间的关系， 测量，神经心理学测试分数，量化EEG和Eps， 单光子发射计算机断层扫描。

Project 4 will focus on regional perfusion patterns in patients with dementia of the Alzheimer's type (AD). One-hundred and twenty-five questionable cases of AD (CDR = 0.5) and 40 normal controls (CDR = 0.) will be followed for a minimum of three years. It is anticipated that approximately 2/3 of the questionable cases (n = 80) will be categorized as AD by the end of the followup. This will permit an examination of the differences in cerebral perfusion as measured by SPECT between questionable cases who were diagnosed as AD on followup and questionable cases who were not. A variety of statistical techniques will be employed to evaluate the SPECT perfusion patterns both visually and quantitatively. These techniques will also permit the evaluation of the relationship between MRI measures, neuropsychological test scores, quantified EEGs and Eps and single photon emission computed tomography.