GENOMICS OF POTASSIUM CHANNELS IN C ELEGANS

描述：这是一项进行一项全面研究的建议 将揭示结构、表达模式和基本功能 线虫体内所有钾通道的特性。该项目将 第一次看到一只动物体内的整个K通道，而不是 有利于任何细胞、组织类型或丰度类别，揭示了 没有完整基因就无法辨别的基因组组织 序列。最初，线虫揭示的所有序列信息 华盛顿大学的基因组计划将被汇编，然后 将确定各个K通道的表达模式。因为 据估计，一个只有302个钾通道的生物体中有100个钾通道 神经元，这些通道中的许多可能处于协调调节下 表达式；这对于复杂的电气行为可能是必需的。这 研究不仅可以得到结构和功能性质的概况， 而且还包括组织分布以及表达的数量和时间。这些 数据可以用作解释人类基因组序列数据的模型， 也可能导致临床应用。

DESCRIPTION: This is a proposal to undertake a comprehensive study that will reveal the structure, expression patterns, and basic functional properties of all potassium channels in C. elegans. The project will provide the first glimpse of the entire K channel set in one animal, without favoring any cell, tissue type or abundance class, revealing aspects of genomic organization that are not discernible without the complete gene sequences. Initially, all sequence information revealed by the C. elegans genomic project at Washington University will be compiled, and then the expression patterns of individual K channels will be determined. Because there are an estimated 100 potassium channels in an organism with only 302 neurons, many of these channels may be under coordinated regulation for expression; this may be required for complex electrical behavior. This study may lead to a profile not only of structure an functional properties, but also tissue distribution and amount and timing of expression. These data may serve as a model for interpreting the human genome sequence data, and may also lead to clinical applications.