IDENTIFICATION AND TREATMENT OF AUTONOMIC AND ELECTROPHYSIOLOGIC ALTERATIONS

这项计划的长期目标是调查 心源性猝死的致心律失常机制 冠状动脉疾病和心室肥厚，两种疾病 占每年30万例突发心脏事件的绝大多数 美国的死亡。我们的总体主题是结构性异常 影响细胞间通讯的心肌导致 致死性脑室的电生理障碍 快速性心律失常。其中一些异常，一旦被发现，就可以 更正或修改，并相应降低 心律不齐。我们假设自主神经系统是一种 细胞间通讯重要调节器及其理解 它的作用将提供对突然发生的事件的洞察 心脏死亡，以选择治疗方案。我们计划了一系列 自主神经支配的侵袭性和非侵入性研究 在心脏正常的个体中，那些患有冠心病和 有心肌肥厚的患者。我们计划给人以同情的形象 应用正电子发射断层扫描技术研究迷走神经心肌模式。它是 预计这一项目的成果将扩大我们对 正常和异常的心脏自主神经如何产生或阻止 心律失常和心脏性猝死。

The long term objectives of this project are to investigate the arrhymogenic mechanisms responsible for sudden cardiac death in patients with coronary disease and ventricular hypertrophy, two disorders accounting for the vast majority of the 300,000 annual sudden cardiac deaths in the U.S. Our overall theme is that structural abnormalities of the myocardium that affect cell-to-cell communication lead to electrophysiological disturbances responsible for the fatal ventricular tachyarrhythmia. Some of these abnormalities, once identified, can be corrected or modified, with a corresponding decrease in the risk of arrhythmia. We hypothesize that the autonomic nervous system is an important modulator of cell-to-cell communication and that understanding its role will provide insight into the events that precipitate sudden cardiac death, into selecting therapeutic options. We plan a series of studies investigating autonomic innervation invasively and noninvasively in individuals with normal hearts, those with coronary artery disease and patients with ventricular hypertrophy. We plan to image sympathetic and vagal myocardial patterns using positron emission tomography. It is anticipated that the results of this project will expand our knowledge of how normal and abnormal autonomic cardiac innervation produces or prevents cardiac arrhythmias and sudden cardiac death.