TRAINING PROGRAM IN BIOORGANIC CHEMISTRY

生物有机培训补助金现正提交续期申请，该基金已 在布兰代斯的科学教育中发挥了重要作用。它给人们带来了 给一群有新奇兴趣和新奇的研究生 能力。这项计划的目标是培训调查人员 可以在生物、生物化学和化学的中间阶段工作。我们 都是成功的。从听取轮换报告来看，很明显， 化学家可以使用和理解分子生物学技术， 生物学家可以合成化合物。这种技能的组合是 在制药行业的需求中，并应促进未来 健康相关研究。该项目一开始没有学生，现在 包含18名学生。实习生是根据他们的能力被任命的 学术成绩和研究能力的证明。在第一个 一年的研究生培训，他们开始参加一个项目，这是 由七门课程组成的核心课程。学生们拿着这些 在该项目的头两年里，他们都在学习课程。核心课程 包括两个学期的高级生物化学(生物化学101a和 101b)，一学期高级有机合成(化学134)，一学期 分子生物学(生物学105)一学期，机械学一学期 有机化学(选自化学131、133或生物化学 202)，一个学期的光谱学高级课程或 晶体结构测定(选自化学132， 229或235)，最后是一门选修课，从 化学、生物化学、生物学或神经科学专业。第一年 学生们还会在不同的实验室进行为期六周的轮换。 在节目中。学生必须完成他们旋转的一半。 集中在化学合成方面的问题。这可以通过以下方式实现 在化学系的教职员工的实验室里轮流工作， 在适当的情况下，在生物化学系的实验室中。一个 最后给出了书面报告和结果的口头陈述 每一次旋转。轮换的目的有两个。第一，是 让学生接触到许多不同的教职员工，以便 他们选择的导师，并为他们提供不同的广泛体验 解决科学问题的方法。其次，旋转是一种 确保我们的所有学生在早期获得实际操作的合成体验 科学事业。此外，学生还参加研讨会和 在他们入住的整个过程中，我们都会给俱乐部写日记。

The Bioorganic Training Grant, which is now submitted for renewal, has played an important role in science education at Brandeis. It gave rise to a group of graduate students with novel interests and novel capabilities. It was the goal of this program to train investigators who can work at the interphase of biology, biochemistry, and chemistry. We have been successful. It is apparent, from listening to rotation reports, that chemists can use, and understand techniques of molecular biology, and biologists can synthesize compounds. This combination of skills is in demand by the pharmaceutical industry, and should facilitate future health related research. The program started with zero students and now contains 18 students. Trainees are appointed on the basis of their strong academic record and evidence of their research ability. In the first year of graduate training they begin to participate in a program, which consists of a core curriculum of seven courses. Students take these courses in their first two years of the program. The core curriculum consists of two semesters of Advanced Biochemistry (Biochemistry 101A & 101B), one semester of Advanced Organic Synthesis (Chemistry 134), one semester of Molecular Biology (Biology 105), one semester of Mechanistic Organic Chemistry (selected from Chemistry 131, 133, or Biochemistry 202), one semester of an advance course in spectroscopy or crystallographic structure determination (selected from Chemistry 132, 229, or 235), and finally one elective, selected from offerings in the Chemistry, Biochemistry, Biology or Neuroscience programs. First year students also undertake six, six-week rotations in different laboratories in the program. The students must complete half of their rotations on problems which focus on chemical synthesis. This can be accomplished by rotating in laboratories of faculty from the Chemistry Department or, where appropriate, in laboratories from the Biochemistry Department. A written report and oral presentation of the results are given at the end of each rotation. The purpose of the rotations is two-fold. First, is to give students exposure to many different faculty so as to facilitate their choice of mentor and to give them a broad experience with different approaches to scientific problems. Second, the rotations are a means of ensuring hands-on synthesis experience for all of our students early in the scientific careers. In addition students participate in seminars and journal clubs throughout their stay.