SENSORY AND SYMPATHETIC EFFECTS ON INTERSTITIAL CYSTITIS

描述(改编自申请人的摘要)：长期目标 这项研究是为了确定感觉和交感肢体的作用。 神经系统对间质性膀胱炎(IC)病理生理的影响。 IC是一种人类痛性、炎症性膀胱疾病。症状 IC(疼痛、尿频和尿急增加)可能会加剧 通过紧张的经历。原因(S)不得而知。一个重要的 阻碍对IC的理解的障碍是缺乏动物 这种疾病的模型。使用NIDDK赠款47537丹麦克朗，本金 调查人员表明，大多数猫被赠送给兽医 对于刺激性排尿的护理，符合以下所有客观标准 可应用于动物的人类IC的诊断。此外， 两者的自然病史和病理生理特征具有可比性。 物种，使猫的IC成为一种极好的自发疾病 模特。 这项为期四年的计划旨在使用CATS和IC来实现 以下目标：1)确定抑制感觉神经传入 有辣椒素的神经元，或有交感传出神经元的 6-羟基多巴胺，可用于临床、膀胱和 IC存在传入、中枢和传出神经系统异常； 2)测定IC和给药对体外培养的影响 膀胱条收缩功能；3)测定远期(6个月) 药物对膀胱最大解决率的影响 异常现象。这些药物的临床疗效与临床疗效的相关性 它们对膀胱和神经系统的影响应该会提供重要的新 对许多观察到的异常现象背后的机制的见解 并建议更合理的治疗方法。 疾病比目前可用的更多。

DESCRIPTION (Adapted from the Applicant's Abstract): The long-term goal of this research is to determine the role of the sensory and sympathetic limbs of the nervous system on the pathophysiology of interstitial cystitis (IC). IC is a painful, inflammatory bladder disease of human beings. The symptoms of IC (pain and increased urinary frequency and urgency) may be exacerbated by stressful experience. The cause(s) is (are) unknown. A significant impediment to progress in understanding IC has been the lack of an animal model of the disease. Using NIDDK grant DK 47537, the principal investigator has shown that the majority of cats presented to veterinarians for care of irritative voiding meet all of the objective criteria for diagnosis of IC in humans that can be applied to animals. Moreover, the natural history and pathophysiologic features are comparable in both species, making IC in cats an excellent spontaneously occurring disease model. This four year proposal is intended to use cats with IC to achieve the following objectives: 1) to determine if inhibiting sensory afferent neurons with capsaicin, or sympathetic efferent neurons with 6-hydroxydopamine, permits resolution of the clinical, bladder, and afferent, central and efferent nervous system abnormalities present in IC; 2) to determine the effects of IC and drug administration on in-vitro bladder strip contractility; and 3) to determine the long-term (6 month) effects of the drug that results in the greatest resolution of bladder abnormalities. The correlation of the clinical effects of these drugs with their effects on the bladder and nervous system should provide important new insights on the mechanisms underlying many of the abnormalities observed in patients with IC, and suggest more rational approaches to treatment of the disease than currently are available.