PHYTOESTROGENS--BONE HEALTH AND CARDIOVASCULAR RISK

拟议培训补助金的中心主题是确定饮食植物雌激素对绝经后妇女的潜在健康益处。第二个主题是确定这种饮食影响是否增强了绝经后妇女耐力运动的健康益处。具体目的是评估9个月每日大豆蛋白摄入和/或耐力运动训练对结果（骨骼健康和心血管风险）的独立和联合影响，这些结果通常通过雌激素替代疗法得到改善。一般的假设是食用膳食大豆补充剂（富含异黄酮染料木素）将有利于绝经后妇女的骨矿物质质量和质量、脂质和脂蛋白谱、内皮功能和血管顺应性。因此，未使用激素替代的绝经后妇女（50-65岁）将被随机分配为每天摄入25g大豆蛋白（50mg染料木素/d）或总牛奶蛋白（安慰剂），并进行9个月的监督耐力运动或家庭拉伸（对照组）。本研究将为膳食植物雌激素对老年妇女骨骼健康和心血管疾病风险的影响提供新的和重要的临床信息。

The central theme of the proposed training grant is to determine the potential health benefits of dietary phytoestrogens in postmenopausal women. A secondary theme is to determine whether such dietary effects potentiate the health benefits of endurance exercise in postmenopausal women. Specific aims are designed to evaluate the independent and combined effect of 9 months of daily soy protein consumption and/or endurance-exercise training on outcomes (bone health and cardiovascular risk) which are typically improved by estrogen replacement therapies. The general hypothesis is that consumption of a dietary soy supplement (enriched with the isoflavone genistein) will favorably effect bone mineral quality and quality, lipid and lipoprotein profiles, endothelial function, and vascular compliance in postmenopausal women. Accordingly, postmenopausal women (50-65 yr) not on hormone replacement will be randomized to consume 25g/d of either soy protein (50mg genistein/d) or total milk protein (placebo) and to either supervised endurance-exercise or home-based stretching (control) for 9 months. This study should provide new and clinically important information on the influence of dietary phytoestrogens on bone health and cardiovascular disease risk in older women.