SODIUM EFFECTS ON BONE METABOLISM

候选人劳拉·卡伯恩医学博士是一个新的调查员， 代谢性骨病近期目标包括获得以下方面的专业知识： 研究设计.这将由共同导师持续提供 博士Genaro Palmieri是代谢性骨病的知名专家， 博士威廉B。Applegate是大型多中心临床试验的专家。 长期目标包括获得必要的技能，做临床 代谢性骨病的临床试验该中心将由 每周一次的统计学和流行病学课程，营养学研讨会， 骨质疏松症和攻读理学硕士学位的项目 流行病学具体研究计划详见下文： 骨代谢、骨密度和骨折的种族差异 据报道，高加索人和非洲裔美国人之间的发病率 高加索人骨生化标志物普遍增加 代谢，降低骨密度和骨折大鼠高于 非裔美国人然而，最近的数据表明， 骨质疏松症和骨质疏松性骨折的发病率可能会在非洲增加， 美国人 环境因素，特别是盐的摄入量，已被证明是 影响高加索人的骨代谢，但尚未在 非洲裔美国人，尽管非洲裔美国人的饮食可能是 钠含量高 本研究建议检查钠负荷的影响，然后 促钙激素和生化标志物的限钠饮食 非洲裔美国人和白人女性的骨代谢。

The candidate, Laura Carbone M.D., is a new investigator in the field of metabolic bone diseases. Immediate goals include acquiring expertise in study design. This will be provided on a ongoing basis by the co-mentors Dr. Genaro Palmieri, a well known expert in metabolic bone disease, and Dr. William B. Applegate, an expert in large multi-center clinical trials. Long term goals include obtaining the skills necessary to do clinical trials in metabolic bone diseases. This will be provided at this center by weekly classes in statistics and epidemiology, seminars in nutrition and osteoporosis and a program leading to a master of science degree in epidemiology. The specific research plan is detailed below: Racial differences in bone metabolism, bone mineral density and fracture rates have been reported between Caucasians and African Americans with Caucasians generally having increased biochemical markers of bone metabolism, decreased bone mineral density and higher fracture rats than African Americans. More recent data, however, suggests that the incidence of osteoporosis and osteoporotic fractures may be increasing in African Americans. Environmental factors, specifically salt intake, have been shown to influence bone metabolism in Caucasians, but have not been studied in African Americans, despite the fact that the African American diet may be high in sodium. This study proposes to examine the effects of sodium load and then a sodium restriction diet of calciotropic hormones and biochemical markers of bone metabolism in African American and Caucasian women.