C KIT SIGNALLING REQUIREMENTS IN TCR LINEAGE COMMITMENT

说明(改编自《首席调查员摘要》)：总体 本项目的目标是定义以下各项的功能后果 蛋白酪氨酸激酶受体c-Kit与其受体的相互作用 T淋巴细胞发育过程中的配体、干细胞因子(SCF)这个 该项目旨在定义功能性细胞间的后果 由c-Kit和SCF调解的对 器官特异性T淋巴细胞发育生物学。具体地说， 研究者提出如下建议：1)确定胸腺的作用 胸腺细胞和肠道T细胞中的基质干细胞因子 发展，2)确定肠上皮细胞来源的作用 干细胞因子在肠道T细胞发育中的作用和3)确定是否 干细胞因子和白介素7是多余或协同的细胞因子 用于胸腺和肠道T细胞发育。

DESCRIPTION (Adapted from the Principal investigator's Abstract): Overall goal of this project is to define the functional consequences of interactions between the protein tyrosine kinase receptor, c-Kit, and its ligand, stem cell factor (SCF) during development of T lymphocytes. The project aims to define the consequences of functional intercellular communication events mediated by c-Kit and SCF that are significant to the biology of organ-specific T lymphocyte development. Specifically, the investigator proposes as follows: 1) to determine the role of thymic stromal-derived stem cell factor in thymocyte and intestinal T-cell development, 2) to determine the role of intestinal epithelial cell-derived stem cell factor in intestinal T-cell development and 3) to determine if stem cell factor and interleukin 7 are redundant or synergistic cytokines for thymic and intestinal T-cell development.