HORMONE ACTION IN THE CENTRAL NERVOUS SYSTEM

描述（改编自申请人的摘要）：本研究的目标 建议是甲状腺激素的机制的特点， 可以影响发育中的大脑神经元迁移， 脑细胞与细胞外基质相互作用的能力 环境 提案的第一部分将描述 甲状腺激素对层粘连蛋白合成和分布的影响 纤维连接蛋白通过星形胶质细胞通过体内和体外方法。 的 第二部分将研究改变整合素ECM相互作用的影响 神经突生长 最后一节将研究甲状腺如何 激素可通过改变整合素介导细胞外基质来源线索 激活细胞内信号通路。 这些研究将 为甲状腺激素的深远影响提供了一种可能的机制 对大脑发育的影响 此外，研究将开始解决 细胞如何相互作用、反应和 适应他们的环境。

DESCRIPTION (Adapted from the applicant's abstract): The goal of this proposal is the characterization of mechanisms by which thyroid hormone can influence neuronal migration in the developing brain by regulating the ability of brain cells to interact with their extracellular environment. The first part of the proposal will characterize the effects of thyroid hormone on synthesis and distribution of laminin and fibronectin by astrocytes by in vivo and in vitro approaches. The second part will examine the effects of altered integrin ECM interaction on neurite outgrowth. The final section will examine how thyroid hormone can regulate ECM derived clues by altering integrin mediated activation of intracellular signaling pathways. These studies will provide a possible mechanism for the profound effects of thyroid hormone on the developing brain. In addition, the studies will begin to address some of the fundamental questions of how cells interact, respond and adapt to their environment.