STEREOCONTROLLED IMINE-ALLYLSILANE CYCLIZATIONS

新工艺的开发，通过这些新工艺可以提高制药效率 可改进的合成是生物医学研究的中心目标。 能够选择性地进行有机反应的新型反应类型的阐明 转型仍然是这一努力的基础。这项研究 在这项拨款申请中提出的是关于发现和 多用途立体调控分子新方法的应用 环扎术。 在上一个供资期间，首席调查员和他的 同事们已经证明了各种立体化学物质的多样性 杂环化合物的制备具有很好的选择性。 实验上直截了当的化学反应。这是意料之中的 这种新的反应类型的使用，以及与 它的变种，将允许快速访问重要的合成类别 用于药理研究的中间体。这份提案概述了我们的 实现这一目标的近期计划和具体细节 在选择的生物活性分子合成中的应用。

The development of new processes by which the efficiency of pharmaceutical synthesis can be improved is a central goal of biomedical research. The elucidation of novel reaction types that enable selective organic transformations remains fundamental to this endeavor. The research proposed within this grant application is concerned with the discovery and application of versatile new methods for stereocontrolled molecular annulation. During the preceding funding period, the Principal Investigator and his coworkers have shown that a variety of stereochemically diverse heterocycles can be prepared with excellent selectivity by an experimentally straightforward class of chemical reactions. It is expected that the use of this new reaction type, as well as mechanistically related variants of it, will permit rapid access to important classes of synthetic intermediates for pharmacological research. This proposal outlines our immediate plans for the pursuit of this objective and details specific applications to the synthesis of selected bioactive molecules.