HIGH RESOLUTION THREE DIMENSIONAL ULTRASOUND IMAGING

描述（改编自申请人的摘要）： 这项工作是发展高分辨率，真实的时间，三 三维（3-D）超声成像系统。 调查人员已 开发了一种真实的时间体积成像系统，目前正在体内进行 试验. 使用第四代相控阵系统的初步结果， 256个发射和256个接收通道，16：1并行接收处理 证明心肌灌注缺陷成像的能力 并提供诸如左和右心室冲程的体积数据 体积和LV质量，无几何假设。 当前图像 分辨率在12厘米范围内约为65立方毫米，这几乎不足以 临床应用。 此外，视野仅限于 65-度金字塔和帧速率大约是每秒20。 本申请 建议开发新的发射和接收技术，以进一步提高 数据采集速率的4倍和新的更高的频率2-D 阵列，以允许净10倍的体积分辨率的改善。 阶段性 开发新一代高分辨率真实的时间容积 提出了一种基于早期工程试验台的成像系统。 新 多波束传输和64：1接收处理中的概念 平行性将在改进的杜克相控阵成像仪上进行测试， 将升级到550个高速发射机和250个频道，所有 数字接收系统 一旦操作概念得到验证， 研究人员建议将这个概念验证系统扩展到1300个 发射和1300个接收通道， vivo.

DESCRIPTION (Adapted from Applicant's Abstract): The overall objective of this work is the development of high resolution, real time, three dimensional (3-D) ultrasound imaging systems. The investigators have developed a real time volumetric imaging system currently undergoing in vivo testing. Initial results using a fourth generation phased array system with 256 transmit and 256 receive channels and 16:1 parallel receive processing demonstrate the capability of imaging perfusion defects in the myocardium and providing volumetric data such as left and right ventricular stroke volumes and LV mass in vivo without geometric assumptions. Current image resolution is about 65 cubic mm at 12 cm range, which is barely adequate for clinical applications. In addition, the field of view is limited to a 65-degree pyramid and frame rates are about 20 per second. This application proposes to develop new transmit and receive techniques to further increase the data acquisition rate by a factor of 4 and new higher frequency 2-D arrays to permit a net 10-fold improvement in volume resolution. The staged development of a new generation, high-resolution real time volumetric imaging system based on an earlier engineering testbed is proposed. New concepts in multiple beam transmission and 64:1 receive processing parallelism are to be tested on the modified Duke Phased Array imager which would be upgraded to 550 high speed transmitters and a 250 channel, all digital receive system. Once operational concepts have been verified, the investigators proposed to expand this proof-of-concept system to 1300 transmit and 1300 receive channels for eventual high quality imaging in vivo.