MR DETERMINATION OF LUMEN CONTOURS AND PLAQUE COMPONENTS

这项合作提案包括成像、生物力学和血管 生物成分。 这份合并提交的文件旨在确定成像， 血液动力学、血液机械学和病理生物学参数， 区分易损动脉粥样硬化斑块。 成像 组件将开发并确认MR血管造影方法， 患者颈动脉分叉的高分辨率3D测量 即将接受动脉内膜切除术 斑块内腔轮廓和组成 将通过离体MR成像和组织学研究进行验证。 目前，识别特定特征，使任何给定的 易破裂的斑块由于缺乏可靠的， 非侵入性方法，可以连续监测斑块形态， 无症状受试者。 高分辨率成像与 生物力学和血管分析提供的病理生理学结果 生物学小组将允许识别斑块特征 这就是易损斑块 有了这些数据， 开展前瞻性监测计划，以确定有风险的患者。

This collaborative proposal has Imaging, Biomechanics and Vascular Biology components. This combined submission seeks to identify imaging, hemodynamic, elastomechanical and pathobiologic parameters that distinguish the vulnerable atherosclerotic plaque. The Imaging component will develop and validate MR angiographic methods that yield high resolution 3D measurements of the carotid bifurcation in patients about to undergo endarterectomy. Plaque lumenal contour and composition will be validated by ex vivo MR imaging and histologic studies. Currently, identification of the specific features that make any given plaque vulnerable to rupture is hampered by the absence of a reliable, non-invasive method that can serially monitor plaque morphology in asymptomatic subjects. The coupling of high-resolution imaging with the pathophysiologic findings provided by the Biomechanics and Vascular Biology groups will allow identification of the plaque characteristics which define the vulnerable plaque. Armed with this data we could embark on a prospective monitoring program to define patients at risk.