COMPUTER-ASSISTED STEREOLOGY FOR MOUSE BRAIN DATABASE

描述：（逐字摘自申请人摘要） 定量的大脑结构数据已经大大增加， 作为CNS疾病模型的遗传操作小鼠的增殖。 在他们的人脑项目联盟下开发的软件定义了 动物模型中正常和病理性脑功能的结构基础。 根据第一阶段赠款，他们已经确定需要一个商业 NeuroZoom版本，具有网络和集成地图集。他们有 开发并验证了新的体视学探头， 分析在小鼠超氧化物中具有点突变的转基因小鼠 SOD-1基因。 在第二阶段的应用中，他们将：1）将NeuroZoom开发成一个 商业支持的跨平台应用程序，并将其扩展到Web，2） 开发软件以整合C57 BU 6和SV 129上的电子鼠标图谱， 3）在转基因小鼠和正常小鼠中定位相关蛋白 模型 他们认为，这些产品的潜在客户是：1） 拥有足够专业知识的实验室进行内部分析 用他们的软件; 2）生物技术公司开发转基因小鼠品系 和外包的全面结构特征;和3） 需要协助制定现场项目的制药公司 他们的分析。 拟议商业应用：不可用

DESCRIPTION: (Verbatim from the Applicant's Abstract) The need to extract quantitative brain structural data has increased substantially with the proliferation of genetically manipulated mice as models of CNS disorders. Software developed under their Human Brain Project consortium define the structural bases for normal and pathologic brain function in animal models. Under the Phase I grant, they have established the need for a commercial version of NeuroZoom with networking and integrated atlases. They have developed and validated new stereology probes by performing stereological analyses of transgenic mice with a point mutation in the mouse superoxide dismutase (SOD-1) gene. In this Phase 2 application, they will: 1) develop NeuroZoom into a commercially-supported, cross-platform application and extend it to the Web, 2) develop software to integrate an electronic mouse atlas on C57BU6 and SV1 29, and 3) map out a related set of proteins in transgenic and normative mouse models. They believe that the potential customers for these products are: 1) laboratories possessing sufficient expertise to carry out the analyses in-house with their software; 2) biotechnology firms developing lines of transgenic mice and outsourcing for their comprehensive structural characterization; and 3) pharmaceutical companies that need assistance in developing an on-site program for their analyses. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE