ULTRA HIGH RESOLUTION SQUID MAGNETOMETERS FOR BIOLOGICAL

描述（改编自申请人的摘要）： 研究是开发超高分辨率，薄膜低温 超导（LTS）SQUID磁强计（UHRSM），集成 拾音圈UHRSM将针对磁场成像进行优化 由动作电流、损伤电流和发育电流产生， 磁化强度和磁化率在孤立的活组织和小 实验动物制剂。在第一阶段，申请人在以下方面的创新 SQUID的设计和制造已经产生了一个可靠的，操作简单， 廉价的SQUID传感器与集成的拾波线圈，其磁通噪声是 可与最好的商用SQUID传感器相媲美。的整合 将SQUID传感器放入低温系统中， 目前已被纳入范德比尔特的一项积极研究计划 大学他们目前的设计允许窗口到SQUID的间距小于 20毫米在第二阶段项目下拟议开发的原型将是 一款价格低廉、模块化、可定制的台式LTS SQUID仪器， 空间分辨率低于100毫米和场灵敏度的生物学研究 大约为1 pT/（平方根Hz）。拟议的文书将能够 用其他任何电或磁的方法都不可能实现的测量 仪器，并应导致新的见解细胞生物学和电 和磁生理学。将进一步利用现有的专门知识， 开发和改进SQUID传感器，用于一般和定制生物磁 需要更高灵敏度SQUID磁强计的应用， 但空间分辨率较低。 拟定商业应用： 低温技术，SQUID设计的专业知识，以及STTR的资助将使我们能够 目标SQUID显微镜的空间分辨率低于100微米， 大约1 pT/Hz-1/2。 LTS SQUID支持具有更高带宽的新测量， 由于上级信噪比而具有更高的空间分辨率和快得多的扫描速率。 这种仪器的市场不是很大，但我们确信可以销售5-10台 每年主要用于科研。 然而，该仪器是否被广泛接受，例如，作为免疫诊断行业的质量控制仪器， 作为对电子元件进行无损检测的仪器，我们每年可以销售数十套系统。

DESCRIPTION (Adapted from Applicant's Abstract): The objective of the proposed research is to develop ultra-high resolution, thin film low-temperature superconductivity (LTS) SQUID magnetometers (UHRSM) with integrated pickup-loops. The UHRSM will be optimized for imaging of the magnetic fields produced by action currents, injury and developmental currents, remanent magnetization, and magnetic susceptibility in isolated living tissue and small experimental animal preparations. During Phase I, the applicants innovation in SQUID design and fabrication already produced a reliable, simple to operate, inexpensive SQUID sensor with integrated pick-up coils, whose flux noise was comparable to the best commercially available SQUID sensors. The integration of the SQUID sensor into a cryogenic system resulted in a prototype instrument currently incorporated into an active research program at Vanderbilt University. Their present design allows a window-to-SQUID spacing of less than 20mm. The prototype proposed to be developed under the Phase II project will be an inexpensive, modular, customizable, bench-top LTS SQUID instrument for biological research with spatial resolution below 100mm and field sensitivities on the order of 1pT/(square root Hz). The proposed instrument will be capable of making measurements that are impossible with any other electric or magnetic instrument, and should lead to new insights into cellular biology and electro- and magnetophysiology. The existing expertise will be exploited further to develop and improve SQUID sensors for general and custom biomagnetic applications which require higher-sensitivity SQUID magnetometers and gradiometers but lower spatial resolution. PROPOSED COMMERCIAL APPLICATION: The cryogenic technology, the expertise in SQUID design, and they STTR grant would allow us to target SQUID microscopes with spatial resolutions below 100 microm with sensitivities around 1 pT/Hz-1/2. The LTS SQUIDs enables new measurements with a higher bandwidth, a higher spatial resolution and a much faster scanning rate due to a superior signal to noise ratio. The market for such an instrument is not enormous, but we are convinced to sell 5-10 systems mainly used in research per year. However, should the instrument be widely accepted, for example, as quality control instrument in the immunodiagnostic industry or as instrument to perform NDE on electronic components, we could sell tens of systems per year.