STEREOSELECTIVE PHARMACOKINETICS AND PHARMACODYNAMICS OF WARFARIN IN THE ELDERLY

研究将检验这样一种假设，即游离对映体华法林 根据维生素K浓度(和/或 饮食摄入量)是华法林氏症的最佳临床预测指标 老年卒中患者的药理学反应。目标是：L。 测定老年卒中患者的药代动力学参数(面积 曲线下和口腔清除)外消旋(完全和自由)和 对映体(完全和游离)华法林。2.测量华法林的反应 时间在格里。中风患者使用凝血酶原时间(PT)和胰岛素抵抗指数(INR)。

Research will test the hypothesis that free enantiomeric warfarin concerntrations, categorized according to vitamin K concentrations (and/or dietary intake) are the best clinical predictors for warfarin's pharmacologic response in geriatric stroke patients. Aims are: l. Determine, in geriatric stroke patients, pharmacokinetic parameters (area under the curve and oral clearance) for racemic (total and free) and enantiomeric (total and free) warfarin. 2. Measure warfarin's response time in ger. stroke patients using (PT) and INR).