EFFECT OF CORRECTION OF SLEEP DISORDERED BREATHING ON DAYTIME HYPERTENSION

本研究将探讨清醒时血压的关系 睡眠引起的呼吸暂停/低通气和高上气道阻力 与打鼾有关。 我们将实验性地消除睡眠 呼吸紊乱（SDB）和打鼾伴鼻持续阳性 轻度和中度高血压患者的气道压力（CPAP）治疗， 确定对48小时动态血压测量的影响 和夜间儿茶酚胺释放。 我们假设，消除夜间呼吸与2 鼻CPAP周将导致血压降低， 轻度/中度高血压受试者，伴有SDB和打鼾，但不会 影响无SDB和打鼾的受试者的动脉压。 我们 预测夜间儿茶酚胺释放的增加将是 与白天血压控制相关， 在CPAP治疗期间的血压。 本研究的主要目的是探讨经鼻持续气道正压通气（CPAP）的临床应用， 可以迅速逆转SDB和打鼾的干预措施， 测量血压和尿中儿茶酚胺的释放， 在干预期间和之后。

This study will investigate the relationship-of waking blood pressure to sleep-induced apnea/hypopnea and high upper airway resistance associated with snoring. We will experimentally eliminate sleep disordered breathing (SDB) and snoring with nasal continuous positive airway pressure (CPAP) treatment in mild and moderate hypertensives and determine the effect on 48 hour ambulatory blood pressure measurements and nocturnal catecholamine release. We hypothesize that the elimination of nocturnal respiratory with 2 weeks of nasal CPAP will result in a reduction in blood pressure in mild/moderate hypertensive subjects with SDB and snoring but will not affect arterial pressure in those subjects without SDB and snoring. We predict that increased nocturnal catecholamine release will be correlated with daytime blood pressure control in subjects who lower their blood pressure during CPAP therapy. The main objective of the study is the application of nasal CPAP, an intervention that can rapidly reverse SDB and snoring, and the measurement of blood pressures and urinary catecholamine release before, during and after the intervention.