NOVEL APPARTUS FOR THE DISINFECTION OF BURN WOUNDS

烧伤患者最容易受到医院感染，需要特殊治疗以避免进一步并发症。烧伤会严重损害甚至破坏人体的环境屏障，损害皮肤，在严重的情况下，损害底层组织。仅在美国，每年就有200万人遭受烧伤，其中100万至300万人住院治疗，12,000人死亡。在成功复苏的患者中，最严重的生存威胁是感染，烧伤败血症是导致死亡的主要原因之一。现代抗菌剂有时会损伤或刺激组织，延缓表皮生长，促进烧伤创面扩大。他们的行为的消极方面超过了他们的应用后的积极影响。在这个SBIR一期中，我们建议开发一种基于电化学产生的臭氧气体的新型烧伤创面消毒装置。在第一阶段，我们打算开发一种程序，允许将已知数量的气态臭氧输送到身体的特定区域，同时防止气体进入周围环境。据设想，该系统的开发将导致满足这一利基市场需求的商业产品，防止或减少烧伤败血症，从而挽救生命。建议的商业应用：臭氧技术正开始成为氯和氯基消毒剂的首选替代品，这是一个每年价值数十亿美元的市场。Lynntech已经开发并申请了一种臭氧发生器的专利，它比传统的臭氧发生器有几个优点。

Burn injury patients are among the most vulnerable to nosocomial infection and require special treatments to avoid further complications. A burn can severely compromise or even destroy the body's environmental barrier through damage to the skin and, in severe cases, the underlying tissues. Each year in the United States alone two million people suffer burn injuries which result in 1,000,000 - 3,000,000 hospitalizations and 12,000 deaths. In successfully resuscitated patients, the most serious threat to survival is infection, with burn-wound sepsis being one of the leading causes of death. Modern antibacterial agents may sometimes damage or irritate tissues, delay epidermal growth, and promote burn wound extension. The negative aspects of their action outweighs the positive effects after their application. In this SBIR Phase I we propose to develop a novel burn wound disinfection unit that will based on electrochemically generated ozone gas. During the Phase I we intend to develop a procedure allow a known amount of gaseous ozone to be delivered to a specified area of the body while, at the same time preventing the gas into the surrounding environment. It is envisaged that the development of the system will lead to a commercial product that fulfills the needs of this niche market, prevents or reduces burn wound sepsis and, thus saves lives. PROPOSED COMMERCIAL APPLICATIONS: Ozone technology is beginning to emerge as the preferred alternative to chlorine and chlorine based disinfectants, a market worth billions of dollars annually. Lynntech has developed and patented an ozone generator that has several advantages over conventional ozone generators.