COMPUTERIZED SCHEDULED GRADUAL REDUCTION FOR SMOKING

描述：该项目的目标是开发一种自助行为干预，以促进治疗抵抗吸烟者减少吸烟。这个名为“减少吸烟生命标志”（LS-SR）的项目将由两个部分组成：一个信用卡大小的手持电脑和一个项目指南。计算机将构建一个计划的，逐步减少（SGR）和维护协议，将减少吸烟率约50%。治疗指南将包括使用电脑和标准行为策略的说明，以促进减少吸烟和预防复发。在第一阶段，将开发治疗方案的原型，并在为期10周的可行性研究中对100名受试者进行评估，随机分配接受两种治疗方案中的一种：1)LS-SR，或2)逐步降低发病率的治疗手册。确定可行性的主要标准将是各组之间在减少吸烟率和减少空气中一氧化碳含量方面的统计显著差异。将评估整个治疗过程中吸烟率、戒烟尝试、戒断症状、对吸烟计划的依从性和计划满意度的变化数据。受试者的定量结果和定性反馈将用于指导进一步的产品开发。在第二阶段，将开发第二代原型计算机，并在大规模临床试验中进行评估。

DESCRIPTION: The goal of this project is to develop a self-help behavioral intervention to promote smoking reduction among treatment resistant smokers. The program, LifeSign for Smoking Reduction (LS-SR) will be composed of two components: a credit-card sized hand-held computer and a program guide. The computer will structure a scheduled, gradual reduction (SGR) and maintenance protocol that will reduce smoking rate by approximately 50%. The treatment guide will contain instructions for using the computer and standard behavioral strategies to facilitate smoking reduction and relapse prevention. During Phase I, a prototype of the treatment program will be developed and evaluated in a 10-week feasibility study with 100 subjects randomly assigned to receive one of two treatment programs: 1) LS-SR, or 2) a treatment manual for gradual rate reduction. The primary criteria for determining feasibility will be statistically significant differences between groups on reductions in smoking rate and reductions in expired air carbon monoxide. Data on changes in smoking rate throughout treatment, quit attempts, withdrawal symptoms, adherence to the smoking schedule, and program satisfaction will be evaluated. Quantitative results and qualitative feedback from subjects will be used to guide further product development. During Phase II, a second generation prototype computer will be developed and evaluated in a large-scale clinical trial with extended follow-up.