ETHANOL AND CD4 CELL DEPENDENT IMMUNITY

在人类和实验动物中的乙醇消费 已被证明会抑制许多特定的免疫功能。它有 假设被抑制的免疫反应可能 有助于增加传染病的流行，并 酗酒者的肿瘤。研究表明，慢性乙醇 消费会抑制T淋巴细胞的辅助功能。CD4T- 辅助细胞可分为两个不同的表型亚集 通过不同的淋巴因子分泌模式发挥作用。Th1细胞 产生细胞介导的免疫；Th2负责 抗体介导的免疫。小鼠的寄生虫感染提供了 感染的主要例子是由任何一个单独控制的 Th1或Th2系统。其中两款车型已经被 彻底调查，(A)大利什曼原虫 感染，免疫力完全依赖于Thl， (B)粪类圆线虫，一种线虫感染，其中 免疫力完全依赖于Th2。乙醇的作用 关于发展对这些疾病的保护性免疫的消费 感染将被确定，从而阐明 乙醇对Th1、Th2功能的影响这项研究的目标是 (I)为行政当局确定适当的方案 乙醇对小鼠的作用，以演示对CD4细胞的影响 功能(Ii)确定乙醇对保护作用的影响 依赖Th1或Th2细胞的免疫反应和(Iii) 研究乙醇引起心脏功能改变的机制。 保护性免疫反应。用这些方法得到的结果 两个寄生虫感染模型将提供有关 酒精摄入对保护性免疫依赖的影响 在CD4细胞上。

Ethanol consumption in humans and in experimental animals has been shown to depress many specific immune functions. It has been hypothesized that the depressed immune response may contribute to the increased prevalence of infectious diseases and tumors in alcoholics. Studies suggest that chronic ethanol consumption depresses T-lymphocyte helper function. CD4 T- helper cells can be divided into two distinct phenotypic subsets acting through different lymphokine secretion patterns. Th1 cells give rise to cell-mediated immunity; Th2 are responsible for antibody-mediated immunity. Parasitic infections in mice provide the premier examples of infections controlled exclusively by either the Thl or the Th2 system. Two of these models have been thoroughly investigated, (a) Leishmania major, a protozoan infection, where immunity is totally Thl dependent and (b)Strongyloides stercoralis, a nematode infection, where immunity is totally Th2 dependent. The effect of ethanol consumption on the development of protective immunity to these infections will be determined, thereby elucidating the effect of ethanol on Thl and Th2 function. The objectives of this study are to (i) to determine the appropriate protocol for the administration of ethanol to mice for the demonstration of an effect on CD4 cell function (ii) to determine the effect of ethanol on protective immune responses dependent on either Thl or Th2 cells and (iii) to investigate the mechanism by which ethanol causes an alteration in the protective immune response. The results obtained with these two parasitic infection models will provide information on the effects of ethanol consumption on protective immunity dependent on CD4 cells.