HHV-6 IN AIDS--MECHANISMS OF CD4 GENE ACTIVATION

描述（改编自申请人摘要）：研究者建议 研究HHV-6与控制CD 4的遗传因子之间的相互作用 通过检测基因表达：1）哪些遗传元件（启动子， 增强子，沉默子）被HHV-6激活/去阻遏，和2）HHV-6 基因负责开启CD 4基因。 这些知识并 揭示了HHV-6的免疫生物学特性及其活性如何 可能会导致艾滋病，也可能有助于更完整的 了解基本的免疫学问题，如控制 免疫活性细胞的基因表达。

DESCRIPTION (adapted from applicant's abstract): The investigators propose to study the interactions between HHV-6 and genetic elements controlling CD4 gene expression by examining: 1) which genetic elements (promoter, enhancer, silencer) are activated/derepressed by HHV-6, and 2) which HHV-6 gene(s) is(are) responsible for turning on the CD4 gene. This knowledge may shed light on the immunobiological properties of HHV-6 and how its activity may contribute to HIV disease, and it may also contribute to a more complete understanding of fundamental immunological questions such as the control of gene expression of immunocompetent cells.