3D COMPUTER AIDED PROSTATE BIOPSY SYSTEM FOR GUDIANCE

这个SBIR项目的主要目标是开发一个三维计算机- 辅助前列腺活检系统，为医生提供指导， 为个体患者执行真实的临床活检程序。的 所提出的系统提供了几种有用的能力，包括（1）三维 主模型的前列腺，包括一个图形模型，显示 主要解剖结构和统计量显示 前列腺癌的概率图将用于选择最佳的 基于模型的活检引导中的活检部位;（2）该3-D主模型 将被覆盖到经腹超声图像空间上， 混合变形配准程序，使标准协议 和/或计划的活组织检查可以利用基于模型和图像的方法来实现， 引导方式;（3）系统将以三维形式记录活检结果 这样可以更好地定义后续的回调重新活检， 可以推导出更精确的算法来估计肿瘤体积和其它 staging参数 这种新的方法将改善现有的临床活检实践， 通过在线多模态可视化和变形概率 活检过程的映射，从而允许更准确地实现 有计划的活组织检查和更具代表性的癌症样本。 因此，这项创新可以大大提高准确性， 前列腺癌的诊断和临床分期，从而提高 治疗计划该系统还将用作培训模块， 模拟和/或教育目的。 拟议的商业应用： 据我们所知，以前没有任何努力， 开发并商业化一种3D计算机辅助前列腺活检 指导、文件和培训系统。显然，市场需求 存在先进的产品，可以为医生提供更好的指导 前列腺穿刺活检的最佳方法 活检部位和电子记录，用于后续研究和/或重新 活组织检查这个SBIR将导致3D计算机辅助前列腺活检 用于医院引导、记录和训练经直肠系统 超声引导下的前列腺穿刺活检。预计将有超过4万人 前列腺癌的死亡人数，每年的影响，建议研发 医疗保健是巨大的。

The primary objective of this SBIR project is to develop a 3-D computer- aided prostate biopsy system to provide physician the guidance in performing real clinical biopsy procedures for individual patient. The proposed system provides several useful capabilities, including (l) A 3-D master model of the prostate, consisting of a graphical model showing major anatomical structures and a statistical volume showing the probability maps of prostate cancer, will be used to select optimal biopsy sites in model-based biopsy guidance; (2) This 3-D master model will be overlaid onto transrecrtal ultrasound image space, through a blended deformable registration procedure, so that the standard protocol and/or the planned biopsies can be realized with a model-based and image- guided fashion; (3) The system will record the result of biopsies in 3-D so that the follow-on call-back re-biopsies can be better defined and a more accurate algorithm may be derived to estimate tumor volume and other staging parameters. This novel approach will improve the existing clinical biopsy practice, through on-line multimodal visualization and deformable probability mapping of the biopsy procedure, thus allowing more accurate realization of planned biopsies and more representative samplings of the cancer. Consequently, this innovation could substantially improve the accuracy of prostate cancer diagnosis and clinical staging, thus improving treatment planning. The system will also be used as a training module for simulation and/or education purposes. PROPOSED COMMERCIAL APPLICATIONS: To the best of our knowledge, there has been no previous effort in developing and commercializing a 3-D computer-aided prostate biopsy system for guidance, documentation and training. Clearly, market demand exists for advanced products that can provide physicians better guidance and documentation in performing prostate needle biopsy with optimized biopsy site and electronic record for follow-on studies and/or re- biopsies. This SBIR would lead to a 3-D computer-aided prostate biopsy system for hospital use to guide, document and train transrectal ultrasound-guided prostate needle biopsies. With over 40,000 predicted deaths from prostate cancer every year, the impact of the proposed R&D to healthcare is enormous.