NEW BIOCOMPATIBLE TI FOR MAXILLOFACIAL PROSTHESES

描述：本研究将开发新的生物相容性材料， 颌面修复术 目前，纯钛还没有 最适合口腔和颌面植入物。 大面积 在颌面部种植体应用中，纯钛金属仍缺乏足够的 实力 另一个问题是控制纯的表面活性。 Ti.存在痕量杂质的非化学计量的氧， 影响纯钛植入物的长期生物相容性和稳定性。 这项研究将开发新的植入生物材料，以克服这些 但保留了纯钛金属的上级生物相容性。 第一阶段将展示铸造高强度钛材料， 强度和化学稳定性，以及一种新的方法， 钛金属表面的稳定化。 第二阶段将扩大 发展成为更广泛的高强度钛材料。 工作 将包括材料分析，表面表征， 性能评估和制造优化。 文化和 将进行临床研究以验证体外试验， 临床性能研究，以显示这些的有益因素 新型植入生物材料。 拟议商业应用：不可用

DESCRIPTION: This research will develop new biocompatible materials for maxillofacial prostheses. At present, pure forms of titanium are not optimum for oral and maxillofacial implants. For large-area maxillofacial implant application, pure Ti metals still lack sufficient strength. Another problem is to control the surface activity of pure Ti. Non-stoichiometric oxygen in the presence of trace impurities which affect the long-term biocompatibility and stability of pure Ti implants. This research will develop new implant biomaterials to overcome these problems but retain the superior biocompatibility of pure Ti metals. Phase I will demonstrate cast high-strength Ti materials for higher bulk strength and chemical stability, and a novel process for the stabilization of Ti metal surfaces. Phase II will expand the development into a wider range of high-strength Ti materials. The work will include materials analysis, surface characterization, and performance evaluation and fabrication optimization. Culture and clinical studies will be conducted to verify in-vitro testings and clinical performance studies to show the beneficial factors for these new implant biomaterials. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE