Unleashing Putida: Biobased Methacrylates for a Sustainable Future

该项目将应用世界一流的生物技术，提供世界上第一个基于生物的、具有商业可行性的甲基丙烯酸酯(MAE)制造工艺。甲基丙烯酸甲酯是聚甲基丙烯酸甲酯(PERSPEX(R))的组成部分，在可持续性方面有了改变游戏规则的改进。三菱化学株式会社(日本三菱化学株式会社)、其英国子公司Lucite International和总部位于英国的生物技术中小企业Ingenza Ltd的合作，从而为目前仅使用不可持续的原料和化学制造工艺生产的产品带来了颠覆性创新。作为占全球370万吨(67亿美元)甲基丙烯酸酯年市场份额三分之一的市场领导者，MCC和Lucite拥有无与伦比的市场潜力和需求知识，以及工艺放大和工程专业知识，为项目产出提供了一条令人信服的进入市场的途径和合理的商业计划。MCC的企业愿景要求迅速实现将生物基甲基丙烯酸酯推向市场，从而根据该公司的Kaiteki原则履行其可持续发展承诺，即减少对化石燃料原材料的依赖，减少用水量和总体上更低的碳足迹。突破性的技术，包括基于荧光激活细胞分类(FACS)的筛选，将选择在基于发酵的生产过程中使用的微生物分离，满足产品耐受性、生产率、操作稳定性和原料转换效率等所需的性能标准。该项目将提供优化的生产有机体和经过验证的可扩展生物制造过程，以降低项目后进入商业中试的风险，为具有成本竞争力的、可持续制造世界上最重要和最多功能的耐用聚合物之一做好准备。因此，该项目旨在提供商业工业生物技术成功的世界领先范例。_PerSpex_(R)是_PerSpex_International的注册商标。

This project will apply world-class biotechnology to deliver the world's first bio-based commercially viable manufacturing process for methacrylate ester (MAE), the building block of poly-methylmethacrylate (Perspex(r)) with a game-changing improvement in sustainability. The collaboration of Mitsubishi Chemical Corporation (MCC --Japan), Lucite International, its UK headquartered subsidiary and UK based biotechnology SME, Ingenza Ltd thereby brings disruptive innovation to a product, currently manufactured solely using unsustainable feedstocks and chemical manufacturing processes. As market leaders with a one-third share of the annual global 3.7 million tons ($6.7bn) methacrylates market, MCC and Lucite possess unrivalled knowledge of the market potential and needs, as well as process scale-up and engineering expertise to provide a compelling route to market and a sound business plan for the project outputs. MCC's corporate vision demands a rapid realisation of biobased methacrylates being brought to the market, thereby fulfilling its sustainability commitments according to the corporation's KAITEKI principles of lower dependence on fossil fuel raw materials, reduced water consumption and overall lower carbon footprint. Ground breaking technology, including fluorescence activated cell sorting (FACS) based screening will select isolates of the microbe used in this fermentation based manufacturing process, meeting required performance criteria of product tolerance, productivity, operational robustness and feedstock conversion efficiency.The project will deliver the optimised production organism and a validated, scalable bio-manufacturing process that de-risks post-project progression to commercial piloting, in preparation for cost-competitive, sustainable manufacturing of one of the world's most important and versatile durable polymers. The project thereby aims to deliver a world-leading example of commercial industrial biotechnology success._PERSPEX_(r) is a registered trademark of _Perspex_ International.