PCA PROGRESSION AND METASTASIS

作为对NIH RFA CA-95-006的回应，密歇根癌症基金会 迈耶湖底特律大都会普伦蒂斯综合癌症中心 （MLPCCCMD）建议在泌尿肿瘤学中制定一个独特的计划 重点是前列腺癌（PCa），它将联合收割机 实验室、临床研究、流行病学以及最终的行为研究 研究项目。这项建议的具体目标是建立一个 工作组使用翻译和临床科学家与集体 专业的前列腺癌生物学检测、筛查和最终治疗， 实施一系列试点项目，收集初步数据 这将使拟议的研究对传统的RO 1更具竞争力 PO 1融资最后将研究成果转化为有用的 诊断、预后和治疗发展的策略 PCa的策略。作为该计划的一部分，8名新教师专门 在翻译和基础水平的PCa研究将被招募， 韦恩州立大学（WSU）。还提供了实验室空间 作为比较基因组杂交分析（CGH）的核心设施。 一个实质性的大学承诺的金额为5美元。一千一百多万 已承诺4年作为这笔发展赠款的配套资金。 这笔资金包括8人的工资（256万美元）， 大学校长的承诺（150万美元），a 5个参与部门的承诺（100万美元）和 CGH核心融资50%的匹配承诺（50，000美元）。 的芯 将组建基础科学和转化研究调查员 围绕模型系统、预测指标、 肿瘤抑制基因，细胞信号机制，凋亡和运动 和入侵。本建议的一个特别重点是审查 非洲裔美国人和高加索人 底特律大都会区测试生物因素负责 在这两个人群中观察到的PCa种族差异。 四个试点项目已被选定为初始资金，它们是 非洲人前列腺上皮细胞系建立 美国和高加索患者的基因组变异检查， 非裔美国人PCa中的细胞增殖， 非洲人前列腺癌前病变的种族观点- 美国人和高加索人，以及一个综合信息管理系统 对于PCa数据。后者将是目前的增强 MLPCCCMD的生物统计学核心。它将包括电子链接， 五个现有的数据库，以及引进 研究者将数据输入该集成系统。最终目标 这项倡议的一个重要目的是将发现从基础科学竞技场转移到 尽快将PCA应用于临床。

In response to NIH RFA CA-95-006 the Michigan Cancer Foundation operating the Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit (MLPCCCMD) proposed to develop within Urologic Oncology a distinct program with a major emphasis in Prostate Cancer (PCa) that will combine laboratory, clinical research, epidemiological and ultimately behavioral research programs. The specific aims of this proposal are to establish a working group using translational and clinical scientists with collective expertise in PCa biology detection, screening and ultimately treatment, To implement a series of pilot projects that will garner preliminary data which will make the proposed research more competitive for traditional RO1 and PO1 funding. Finally to translate research results into useful strategies form diagnosis prognosis and development of treatment strategies from PCa. As part of this program 8 new faculty specializing in PCa research at the translational and basic level will be recruited to Wayne State University (WSU). Laboratory space has been provided as well as a core facility in comparative genomic hybridization analysis (CGH). A substantial university commitment in the amount of $5. 11 million over 4 years has been pledged as matching money to this development grant. This funding includes salary for 8 individuals ($2.56 million), a commitment from the President of the university ($1.5 million), a commitment from 5 participating departments ($1.0 million) and a commitment for 50% match for the CGH Core Facility ($50,000). A core of basic science and translational research investigators will be formed around the interactive themes of model systems, prognostic indicators, tumor suppressor genes, cell signalling mechanisms, apoptosis and motility and invasion. A particular emphasis of this proposal is an examination of the African-American population and the Caucasian population in the Detroit Metropolitan area to test for biological factors responsible for the racial differences observed in PCa within these two population groups. Four pilot projects have been chosen for initial funding and they are the establishment of human prostate epithelial cell lines from African American and Caucasian patient examination of genomic alternations and cellular proliferation in PCa of African Americans, the study on the racial perspectives on premalignant lesions of the prostate in African- Americans and Caucasians, and an integrated information management system for PCa data. The latter will be an enhancement of the current biostatistics core of the MLPCCCMD. It will include an electronic link of five currently existing databases as well as the introduction of investigator initiated data into this integrated system. The final goal of this initiative is to move discoveries from the basic science arena to clinical applications for Pca as rapidly as possible.