COGNITIVE/LINGUISTIC FACTORS IN ACQUIRED DYSLEXIA

阅读能力的中断是一种常见的 局灶性脑损伤的后果，如中风。“后天” 阅读障碍，发生在患病前识字的成年人，可以采取一个 许多不同的形式似乎反映了选择性 认知操作的不同方面的损害， 通常支持阅读。该项目的长期目标是 开发一个阅读模型， 业务及其相互作用。这样的模型将有一个 各种应用程序如果特定的睡眠障碍症状可以 被解释为由可识别的处理缺陷引起的， 模型，则可以将修复症状的尝试集中在 负责的代表或过程。 此外，离散 通过研究确定的加工成分， 患有神经性阅读障碍的患者可能会 最终将被证明与 可识别的神经生物学过程。具体目标 下一个项目期间继续调查关系 在不同的处理组件中， 参与阅读。 实验提出了扩展 重点考察句法和语义的贡献 对阅读和写表现的操纵。三 将采用与前一项目相同的方法 期主要方法是对患有以下疾病的患者进行检测 获得性阅读障碍和对照组的实验电池 旨在识别假设的 加工组件。 第二种方法是 继续开展靶向治疗研究， 这些尝试是为了改变患者的特定方面， 处理能力，以便改变对其他人的影响 组件可以进行评估。第三种方法是发展 的实现计算版本的指导， 加工模型，因此，关于时间进程的具体假设 并且可以探索特定组分的相互作用。

Disruption of the ability to read is a common and debilitating consequence of focal brain injury, suCh as stroke. The "acquired" dyslexias, occurring in premorbidly literate adults, can take a number of distinct forms that appear to reflect selective impairment of different aspects of the cognitive operations that normally support reading. The long-term goal of this project is to develop a model of reading that describes those cognitive operations and their interactions. Such a model would have a variety of applications. If specific dyslexic symptoms can be interpreted as arising from identifiable processing deficits within a model, then attempts to remediate symptoms can be focused on the responsible representation or process. Moreover, discrete components of processing that are identified through studies of the patients with neurogenic reading impairments would be likely to be the components that will ultimately prove to be related to identifiable neurobiological processes. The Specific Aims for the next project period continue investigations of the relationships among the distinct processing components that are hypothesized to be involved in reading. Experiments are proposed to extend the focus to investigate the contribution o syntactic and semantic manipulations on reading and writing performance. Three methodological approaches will be used, as in the previous project period. The primary method will be the testing of patients with acquired dyslexia and control subjects on an experimental battery designed to identify selective impairments within hypothesized processing components. A second methodological approach to be continued is the development of targeted treatment studies, in which attempts are made to change specific aspects of patients' processing abilities so that th effects of change on other components can be assessed. A third approach is the development of an implemented computational version of the guiding processing model, so that specific hypothese about the time-course and interactions of specific components can be explored.