MECHANISMS OF ACOUSTIC PERCEPTION AND ORIENTATION

描述：实验室研究的总体目标是 回声定位的行为、生理和解剖学相关性， 听着胡子蝙蝠的声音 该提案侧重于两个主题： 通过OC传出神经和内耳的3D成像控制耳蜗。 具体目标有五个：1。 监测MOC活动和诱导变化 在回声定位中的耳蜗力学。 其中包括示范 与脉冲的发射和感知有关的阶段性活动 回声和紧张性活动与总声输入的关系。 2. 证明MOC活动、声学感知、 回声定位行为（DS补偿）和神经相关的 回声定位（例如调谐曲线锐度）。 3. 确定声学 导致MOC诱导抑制崩溃的刺激参数 耳蜗阻尼，并证明这种故障是由于 相互作用，w/在乙酰胆碱和GABA的耳蜗，这两个已知的发射机， 介导传出活动。 4. 建立周边课程， 分布，以及不同组织中纤维和终末的排列 耳蜗的功能区域（例如，60 - 90 kHz中央凹区域等 宽调谐段）。 5. 完成MRM图像的收集 蝙蝠和其他哺乳动物的耳蜗，并探讨建模（有限元 分析-有限元分析）的振动模式，给定的尺寸， MRM重建耳蜗。

DESCRIPTION: The overall goal of the laboratory's research is the behavioral, physiological, and anatomical correlates of echolocation and hearing in the mustached bat. This proposal focuses on two main themes: control of the cochlea by OC efferents and 3D imaging of the inner ear. There are five specific aims: 1. Monitor MOC activity and induced changes in cochlear mechanics during echolocation. This includes the demonstration of phasic activity in relation to the emission of pulses and perception of echoes and tonic activity in relation to the total acoustic input over time. 2. Demonstrate links between MOC activity, acoustic perception, echolocation behavior (DS compensation) and neural correlates of echolocation (e.g. tuning curve sharpness). 3. Determine the acoustic stimulus parameters that cause the breakdown of MOC induced suppression of cochlear damping and demonstrate that this breakdown is due to the interaction, w/in the cochlea of ACh and GABA, the two transmitters known to mediate efferent activity. 4. Establish the peripheral course, distribution, and arrangement of LOC fibers and terminals in different functional areas of the cochlea (e.g. 60 - 90 kHz foveal regions and more broadly-tuned segments). 5. Complete the collection of MRM images of the cochleae of bats and other mammals and explore the modeling (finite element analysis - FEA) of vibrational patterns, given the dimensions of the cochleae reconstructed from MRM.