STEREOCONTROLLED IMINE-ALLYLSILANE CYCLIZATIONS

新工艺的开发， 合成的改进是生物医学研究的中心目标。 新的反应类型的阐明，使选择性有机 变革仍然是这一奋进的基础。 研究 在此授权申请中提出的是关于发现和 立体定向分子调控的新方法及其应用 成环 在上一个资助期间，首席研究员及其 同事们已经表明，各种立体化学上不同的 杂环化合物可以通过以下方法以优异的选择性制备： 实验上简单的化学反应。 预计 使用这种新的反应类型，以及机械相关的 它的变体，将允许快速获得重要类别的合成 药理学研究的中间体。 该提案概述了我们的 实现这一目标的近期计划和具体细节 应用于所选生物活性分子的合成。

The development of new processes by which the efficiency of pharmaceutical synthesis can be improved is a central goal of biomedical research. The elucidation of novel reaction types that enable selective organic transformations remains fundamental to this endeavor. The research proposed within this grant application is concerned with the discovery and application of versatile new methods for stereocontrolled molecular annulation. During the preceding funding period, the Principal Investigator and his coworkers have shown that a variety of stereochemically diverse heterocycles can be prepared with excellent selectivity by an experimentally straightforward class of chemical reactions. It is expected that the use of this new reaction type, as well as mechanistically related variants of it, will permit rapid access to important classes of synthetic intermediates for pharmacological research. This proposal outlines our immediate plans for the pursuit of this objective and details specific applications to the synthesis of selected bioactive molecules.