EPIDEMIOLOGY OF MARINE FATTY ACIDS AND PREECLAMPSIA

描述：(改编自《调查者摘要》)先兆子痫， 在美国，产妇死亡的第三大原因是 早产、胎儿发育迟缓和 围产期死亡率。子宫胎盘低灌注率被认为是 先兆子痫的原发缺陷。内皮细胞损伤也是 在子痫前期的发病机制中起重要作用。之前的调查人员 都集中在这些血管侮辱的原因上。调查结果来自 几个学科表明先兆子痫与 过度的脂质过氧化，氧化-抗氧化失衡，以及 N-3和n-6多不饱和脂肪酸的失衡，以及 血栓烷和前列环素的合成。目前还不清楚 这些特征是先兆子痫还是次要的 疾病过程。作者建议进行一项前瞻性队列研究 妊娠未产妇的研究。建议的总体目标是 研究是评估母亲是否以及在多大程度上摄入 饮食中的海洋脂肪酸和抗氧化维生素与 先兆子痫的风险。作者将收集母亲的血液和尿液 从1500名妇女队列中采集的样本 怀孕了。同时，有关医疗和医疗的信息 行为特征将通过访谈收集。医疗 将审查记录，以便收集以下信息 妊娠结局。血液和尿液样本将被处理并 储存在-70℃，直到分析。母亲摄取海洋脂肪酸和 抗氧化维生素将通过生化和饮食进行评估。 方法：研究方法。二十烷类化合物和脂质过氧化的指示物也将 已评估。采用嵌套病例队列抽样设计，作者将 确定90名患有先兆子痫的妇女和同等数量的患有子痫前期的妇女 妊娠期高血压。随机挑选的150名女性 来自整个研究队列(N-1500)将作为单一参考 所有抽样个体的分组。统计分析将重点放在 测定：(1)脂质过氧化和二十烷类化合物的程度 妊娠前三个月的合成与随后的风险有关 先兆子痫和妊娠期高血压；以及(2)是否 这些代谢因素与母亲的饮食有关。这个 研究人员表示，研究结果的临床应用可能 导致及早发现有先兆子痫和AN风险的妇女 有效干预。

DESCRIPTION: (Adapted from Investigator's Abstract) Preeclampsia, the third leading cause of maternal mortality in the United States, is an important cause of preterm delivery, fetal growth retardation, and perinatal mortality. Uteroplacental hypoperfusion is thought to be the primary defect in preeclampsia. Endothelial cell damage is also important in the pathogenesis of preeclampsia. Previous investigators have focused on the cause of these vascular insults. Findings from several disciplines indicate that preeclampsia is associated with excessive lipid peroxidation, oxidant-antioxidant imbalance, as well as an imbalance in n-3 and n-6 polyunsaturated fatty acids, and in thrombooxane and prostacyclin synthesis. Presently it is unknown whether these features precede preeclampsia or are secondary to the disease process. The authors propose to conduct a prospective cohort study of pregnant nulliparous women. The overall aim of the proposed research is to evaluate whether, and to what extent, maternal intake of dietary marine fatty acids and antioxidant vitamins are associated with risk of preeclampsia. The authors will collect maternal blood and urine specimens from a cohort of 1500 women during the first trimester of pregnancy. At the same time, information regarding medical and behavioral characteristics will be collected by interview. Medical records will be reviewed in order to collect information regarding pregnancy outcome. Blood and urine specimens will be processed and stored at -70C until analysis. Maternal intake of marine fatty acids and antioxidant vitamins will be assessed using biochemical and dietary methods. Eicosanoids and indicators of lipid peroxidation will also be evaluated. Using a nested case-cohort sampling design, the authors will identify 90 women with preeclampsia and an equal number of women with gestational hypertension. One hundred and fifty women randomly selected from the entire study cohort (N- 1500) will serve as a single reference group for all individuals sampled. Statistical analyses will focus on determining: (1) the extent to which lipid peroxidation and eicosanoid synthesis in the first trimester are associated with subsequent risk of preeclampsia and gestational hypertension, respectively; and (2) whether these metabolic factors are associated with maternal diet. The investigators state that clinical applications of study findings may result in early identification of women at risk of preeclampsia and an effective intervention.