MICROSENSOR FOR INTRAMUSCULAR PRESSURE MEASUREMENT

描述（改编自申请人的摘要）：目前，没有 存在直接测量力产生的实用方法， 在动态人体运动过程中的单个肌肉。 手动肌肉测试 不能准确估计肌肉力量， 走路的能力。 关节扭矩的测量不充分，因为 几块肌肉通常有助于扭矩的发展。 植入 肌腱上的屈曲换能器是高度侵入性的，并且对于常规的 使用. 综合肌电图通常用于提供 肌肉收缩的量化。 然而，问题仍然是， 肌电图活动不能提供肌肉的定量测量 动态条件下的张力。 另一种可测量的参数 与肌肉力量相关的是肌肉内压力。 市售 肌内压力传感器对于最佳舒适度来说太大。 微传感器技术现在可用于构造 其尺寸与用于肌电描记术的细导线大致相同 分析. 该项目的总体目标是开发和测试一种光纤 微传感器，可用于路由，肌肉的临床测量 功能 本研究的具体目标是：（a）继续发展 a）测量肌内压力的光纤微传感器，B）确定 肌内压、肌节长度 以及正常肌肉在等长和动态条件下的肌张力 在动物模型中，以及c）开发肌肉内注射的数学模型， 压力，以建立一个理论基础，了解 实验测量。 本研究检验的假设是，肌内压力是 直接关系到两个独立的现象;即，被动延长 肌肉纤维和由肌肉纤维产生的主动力。 成功 这种微传感器的发展将成为一种强大的新工具， 量化肌肉功能。 这个装置将有助于提供一个 更好地表现动态条件下的肌肉张力。 它将 成为临床步态分析的重要工具，旨在改善 患有神经肌肉疾病的残疾患者的活动能力， 瘫痪，肌肉萎缩症，肌萎缩侧索硬化症，中风，头部 损伤、脊髓损伤和脊髓灰质炎。 最终目标是利用 这种用于临床决策的微传感器， 残疾人。

DESCRIPTION (Adapted from the Applicant's Abstract): Currently, no practical method exists for direct measurement of force production from individual muscles during dynamic human movement. Manual muscle tests do not give an accurate estimate of muscle strength which can predict the ability to walk. Measurements of joint torque are inadequate because several muscles often contribute to torque development. Implantation of a buckle transducer on a tendon is highly invasive and impractical for regular use. The integrated electromyogram is customarily used to provide quantification of muscle contraction. However, the problem remains that the electromyographic activity cannot provide a quantitative measure of muscle tension under dynamic conditions. An alternative, measurable parameter related to muscle force is intramuscular pressure. Commercially available intramuscular pressure transducers are too large for optimum comfort. Microsensor technology is now available to construct transducers that are approximately the same size as the fine wires used for electromyographic analysis. The overall objective of this project is to develop and test a fiber optic microsensor that can be used for routing, clinical measurement of muscle function. The specific aims of this study are a) to continue development of a fiber optic microsensor to measure intramuscular pressure, b) to determine the relationships between intramuscular pressure, muscle sarcomere length, and muscle tension under isometric and dynamic conditions for normal muscle in an animal model, and c) to develop a mathematical model of intramuscular pressure in order to establish a theoretical basis for understanding the experimental measurements. The hypothesis examined by this study is that intramuscular pressure is directly related to two independent phenomena; namely, passive elongation of muscle fibers and active force generation by muscle fibers. Successful development of this microsensor will result in a powerful new tool for quantifying muscle function. This device will be useful in offering a better representation of muscle tension under dynamic conditions. It will become an essential tool in clinical gait analysis aimed at improving mobility of disabled patients with neuromuscular disorders such as cerebral palsy, muscular dystrophy, amyotrophic lateral sclerosis, stroke, head injury, spinal cord injury, and poliomyelitis. The ultimate goal is to use this microsensor for clinical decision making to improve the mobility of disabled individuals.