HORMONE ACTION IN THE CENTRAL NERVOUS SYSTEM

描述(改编自申请人的摘要)：本报告的目标 建议是对甲状腺激素的机制进行表征 可以通过调节影响发育中大脑中的神经元迁移 脑细胞与细胞外相互作用的能力 环境。提案的第一部分将描述 甲状腺激素对层粘连蛋白合成和分布的影响 星形胶质细胞纤维连接蛋白的体内和体外研究。这个 第二部分将研究改变的整合素ECM相互作用的影响 在轴突生长上。最后一节将检查甲状腺如何 激素通过改变整合素介导的方式调节ECM来源的线索 激活细胞内信号通路。这些研究将 为甲状腺激素的深层作用提供可能的机制 在发育中的大脑上。此外，这些研究将开始解决 关于细胞如何相互作用、响应和 适应他们的环境。

DESCRIPTION (Adapted from the applicant's abstract): The goal of this proposal is the characterization of mechanisms by which thyroid hormone can influence neuronal migration in the developing brain by regulating the ability of brain cells to interact with their extracellular environment. The first part of the proposal will characterize the effects of thyroid hormone on synthesis and distribution of laminin and fibronectin by astrocytes by in vivo and in vitro approaches. The second part will examine the effects of altered integrin ECM interaction on neurite outgrowth. The final section will examine how thyroid hormone can regulate ECM derived clues by altering integrin mediated activation of intracellular signaling pathways. These studies will provide a possible mechanism for the profound effects of thyroid hormone on the developing brain. In addition, the studies will begin to address some of the fundamental questions of how cells interact, respond and adapt to their environment.