FUNCTION OF GLUTAMATE RECEPTORS IN VISUAL CORTEX

描述：各种实验表明，代谢性谷氨酸 感受器在视觉的感觉依赖性可塑性中起重要作用 大脑皮层。同时，代谢性谷氨酸受体有一种 多种因素对细胞电生理特性的影响 视觉皮质，而这些还没有得到广泛的研究。 突触前抑制、突触后兴奋和突触增强 对NMDA的反应都被证明是发生的，但每一种都被研究过 在大脑皮层的一层，而不是在其他层。最有可能的是这些 不同的影响发生是因为有不同的代谢性 谷氨酸受体(由分子生物学技术定义)定位 在大脑皮层的不同位置。使用原位杂交，以及 通过产生针对特定代谢性谷氨酸的抗体 受体(由分子生物学技术定义)位于 大脑皮层的不同部位。使用原位杂交，以及 通过产生针对特定代谢性谷氨酸的抗体 受体，表明在分布上存在层流差异 这些受体随着年龄的增长而变化。此应用程序 建议研究层流的差异和发展。 代谢型谷氨酸受体的电生理效应。这个 假说是这些电生理特性使它 很可能突触后细胞会在突触前细胞 在发育的特定年龄引发火灾，导致加强 通过Hebbian机制突触，这可能与 感官可塑性的临界期。

DESCRIPTION: A variety of experiments suggest that metabotropic glutamate receptors are important in sensory-dependent plasticity in the visual cortex. At the same time, metabotropic glutamate receptors have a variety of effects on the electrophysiological properties of cells in the visual cortex, and these have not been extensively studied. Presynaptic inhibition, postsynaptic excitation, and potentiation of the response to NMDA have all been shown to occur, but each has been studied in one layer of the cortex and not in others. Most likely these different effects occur because there are a variety of metabotropic glutamate receptors (defined by molecular biological techniques) located at different places in the cortex. Work with in situ hybridization, and with antibodies created against particular metabotropic glutamate receptors (defined by molecular biological techniques) located at different places in the cortex. Work with in situ hybridization, and with antibodies created against particular metabotropic glutamate receptors, shows that there are laminar differences in the distribution of these receptors, and these change with age. This application proposes to study the laminar differences and development of the electrophysiological effects of metabotropic glutamate receptors. The hypothesis is that these electrophysiological properties make it more likely that the postsynaptic cell will fire when the presynaptic cell fires at particular ages in development, leading to strengthening of synapses through a Hebbian mechanism, which may correlate with the critical period for sensory-dependent plasticity.