NUTRITION, GENES AND HIP FRACTURE RISK IN UTAH

描述：(改编自《调查员摘要》)调查员 提出一项基于人群的病例对照研究，研究小说的作用 营养和遗传因素在犹他州髋部骨折病因中的作用 居民，年龄在50岁或以上。他们将招募950名女性和950名男性 从所有髋部骨折的随机样本中随机抽取髋部骨折 1997-2000年犹他州居民和相同数量的性别和年龄匹配的居民 控制。以下假设将得到检验。1.低摄入量 蛋白质与髋部骨折风险增加有关；分析将 扩大到包括蛋白质摄入量和赖氨酸的来源和质量 入口处。分析中的协变量将包括总能量、脂肪、 碳水化合物、钙和维生素D。2.候选基因的等位变异 与骨质疏松症相关的标志物会增加髋部骨折的风险。 他们将研究与骨骼形成和重塑有关的基因， 包括COL1A1和COL1A2，编码1型链的基因 前胶原、维生素D受体、骨钙素、骨联素和 骨桥蛋白。目的是评估髋部骨折的风险。 在一个有代表性的人类的背景下对这些候选基因 人口。3.上述候选基因和营养物质相互作用， 相加或相乘，增加髋部骨折的风险。 携带骨质疏松高危等位基因的人可能更容易患上骨质疏松症 导致髋部骨折的营养因素和其他环境因素。 印第安人髋部骨折的初步研究(50例，100例) 控制)将制定适当的方法，包括饮食评估。 美洲原住民之间的裂痕还没有得到充分的研究，这一少数群体 包括骨密度差异较大的亚组，饮食 习惯、生活方式习惯、环境暴露和遗传特征。这个 调查人员表示，提议的多学科方法可能会导致 有效的公共卫生干预，以减轻髋部骨折的负担。

DESCRIPTION: (Adapted from Investigator's Abstract) The investigators propose a population-based case-control study of the role of novel nutritional and genetic factors in the etiology of hip fractures in Utah residents, ages 50 years or older. They will recruit 950 women and 950 men with incident hip fractures from a random sample of all hip fractures among Utah residents during 1997-00 and an equal number of sex- and age-matched controls. The following hypotheses will be tested. 1. Low intake of protein is associated with an increased risk of hip fracture; analyses will be extended to include source and quality of protein intake and lysine intake. Covariates in analyses will include intakes of total energy, lipid, carbohydrate, calcium, and vitamin D. 2. Allelic variants of candidate gene markers associated with osteoporosis increase the risk of hip fracture. They will study genes that are involved in bone formation and remodeling, including COL1A1 and COL1A2, the genes that encode the chains of type 1 procollagen, the vitamin D receptor, osteocalcin, osteonectin, and osteopontin. The goal is to evaluate the risk of hip fracture attributable to these candidate genes within the context of a representative human population. 3. The candidate genes and nutrients mentioned above interact, additively or multiplicatively, to increase the risk of hip fracture. Individuals with high-risk alleles for osteoporosis may be more susceptible to nutritional and other environmental causes of hip fracture. A pilot study of hip fractures among Native Americans (50 cases, 100 controls) will develop appropriate methods, including dietary assessment. Fractures among Native Americans are understudied and this minority group includes subgroups with considerable variation in bone density, dietary habits, lifestyle habits, environmental exposures, and genetic traits. The investigators state that the multidisciplinary approach proposed may lead to effective public health interventions to reduce the burden of hip fractures.