EXCITATORY AMINO ACIDS AND CONDITIONED HYPERACTIVITY

描述：（申请人摘要） 这项提案的目标是描绘大脑区域，并确定 非NMDA受体的作用和位置的可卡因相关激活 刺激。 有证据表明，大脑边缘区域，特别是大脑皮层， 延髓核参与条件反应的表达， 精神兴奋剂药物线索 最近的证据表明， NMDA和非NMDA受体机制。 NMDA受体已经被 与可卡因和刺激物之间联系的发展有关 多次与可卡因混合 更有临床意义的是 暗示非NMDA受体参与行为反应的表达 可卡因相关的刺激。 这里提出的研究将测试 假设非NMDA受体机制参与可卡因诱导的 条件性多动症 将输注非NMDA受体拮抗剂 之前被认为是由条件反射激活的大脑区域 Fos免疫组织化学法。 PI的最终目标是表明， 可以开发新的药物疗法用于治疗条件性 对可卡因上瘾的人

DESCRIPTION: (Applicant's Abstract) The goal of this proposal is to delineate the brain regions and determine the role and location of non-NMDA receptors activated by cocaine-related stimuli. Evidence suggests that limbic regions, and in particular, the nucleus accumbens is involved in the expression of conditioned responses to psychomotor stimulant drug cues. Recent evidence suggests important roles for both NMDA and non-NMDA receptor mechanisms. NMDA receptors have been implicated in the development of associations between cocaine and stimuli repeatedly paired with cocaine. Of more clinical significance are findings implicating non-NMDA receptors in the expression of the behavioral responses to cocaine-related stimuli. The studies proposed here will test the hypothesis that non-NMDA receptor mechanisms participate in cocaine-induced conditioned hyperactivity. A non-NMDA receptor antagonist will be infused into brain regions previously identified as being activated by conditioning using Fos immunohistochemistry. The ultimate goal of the PI is to show that novel pharmacotherapies may be developed for the treatment of conditioned cravings in individuals addicted to cocaine.