EXCITATORY AMINO ACIDS AND CONDITIONED HYPERACTIVITY

描述：(申请人摘要) 这项提议的目标是勾勒出大脑区域并确定 可卡因相关激活的非NMDA受体的作用和定位 刺激物。有证据表明，边缘区域，特别是 伏隔核参与条件性反应的表达 精神运动性兴奋剂药物提示。最近的证据表明了重要的作用 对于NMDA和非NMDA受体机制。NMDA受体已经被 与可卡因和刺激物之间的联系的发展有关 反复与可卡因配对。更具临床意义的是这些发现 非NMDA受体参与行为反应的表达 与可卡因相关的刺激。这里提出的研究将测试 非NMDA受体机制参与可卡因诱导的假说 条件性多动。一种非NMDA受体拮抗剂将被注入 进入先前被识别为被条件反射激活的大脑区域 Fos免疫组织化学染色。PI的最终目标是表明 可能会开发新的药物疗法来治疗条件性心脏病 对可卡因上瘾的人的渴望。

DESCRIPTION: (Applicant's Abstract) The goal of this proposal is to delineate the brain regions and determine the role and location of non-NMDA receptors activated by cocaine-related stimuli. Evidence suggests that limbic regions, and in particular, the nucleus accumbens is involved in the expression of conditioned responses to psychomotor stimulant drug cues. Recent evidence suggests important roles for both NMDA and non-NMDA receptor mechanisms. NMDA receptors have been implicated in the development of associations between cocaine and stimuli repeatedly paired with cocaine. Of more clinical significance are findings implicating non-NMDA receptors in the expression of the behavioral responses to cocaine-related stimuli. The studies proposed here will test the hypothesis that non-NMDA receptor mechanisms participate in cocaine-induced conditioned hyperactivity. A non-NMDA receptor antagonist will be infused into brain regions previously identified as being activated by conditioning using Fos immunohistochemistry. The ultimate goal of the PI is to show that novel pharmacotherapies may be developed for the treatment of conditioned cravings in individuals addicted to cocaine.