EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

该申请要求提供资金，以翻新容纳 斯隆凯特琳癌症研究所的回旋加速器 （SKI）.这台仪器已经28岁了。虽然它是足够的 生产用于体外研究的新放射性核素， 日常生产的放射性核素所需的关键 临床研究。为了确保SKI在以下方面的持续领导作用， 依靠回旋加速器进行癌症早期诊断和治疗的研究 和其他疾病，该文书将被替换为一个新的国家- 最先进的负离子双粒子回旋加速器 购买新回旋加速器的资金不要求在本 应用程序.然而，需要资金开展必要的 SKI回旋加速器/放射化学核心研究的更新和升级 设施实验室将容纳替换回旋加速器。改造 不仅要安装仪器，而且要提高 安全和生产力的设施建设和安装热 与回旋加速器相关的放射化学领域的细胞。 复杂的代谢蛋白质常被用放射性示踪剂阐明 方法论由于其特异性高，检测限低， 精确定量的能力，放射性示踪剂允许研究人员使用 限制数量和有限采样，以生成准确和精确的 数据随着危险废物管理法规的加强， 材料，需要短寿命，回旋加速器产生的放射性核素 继续升级虽然现有的回旋加速器可用于 目前的努力，机构倡议，建立一个整体 正电子发射断层扫描（PET）中心无疑将负担过重 仪器和工作人员的能力，以维持 生产要求。 因此，对现有设施的翻修是 一项主要的SKI倡议，建立正电子发射断层扫描（PET） 中心这一承诺使一些研究得以进行， 在诊断、临床和基础生物医学研究中开展的 与多种类型的肿瘤有关。

This application requests funding to renovate the space that houses the research cyclotron of the Sloan Kettering Institute for Cancer Research (SKI). This instrument is 28 years old. While it is adequate for the production of new radionuclides for in vitro studies, it cannot be relied upon for the day-to-day production of radionuclides needed for critical clinical studies. In order to ensure SKI's continuing leadership role in cyclotron-dependent research into early diagnosis and treatment of cancer and other diseases, the instrument will be replaced with a new state-of- the-art negative ion, dual particle cyclotron. Funds for the purchase of the new cyclotron are not requested in this application. Funds are requested, however, to carry out the necessary renovation and upgrading of SKI's cyclotron/Radiochemistry Core Research Facility laboratory will house the replacement cyclotron. The renovation is necessary not only to install the instrument but also to enhance the safety and productivity of the facility by constructing and installing hot cells in the Radiochemistry area associated with the Cyclotron. Complex metabolic proteins have often been elucidated using radio-tracer methodology. With their high specificity, low detection limits and the ability for precise quantitation, radio-tracers allow investigators to use restricted quantities and finite sampling to generate accurate and precise data. With tightening regulation on management of hazardous waster materials, the need for short-lived, cyclotron-produced radionuclides continues to escalate. While the existing cyclotron is serviceable for the present effort, the Institutional initiative to establish a Whole Body Positron Emission Tomographic (PET) Center will unquestionably overburden the capabilities of the instrument and staff necessary to maintain the production requirements. Thus, the renovation of this existing facility is a critical component of a major SKI initiative to establish Positron Emission Tomographic (PET) Center. This commitment has allowed for a number of studies to be undertaken in the diagnostic, clinical and basic biomedical research related to numerous types of tumors.