A Conditional System for Inexpensive Manufacture of Attenuated Vaccines

新出现的传染病有可能导致大量和广泛的人类死亡，对全球稳定构成越来越大的威胁。具有全球意义的EID最常见的是由病毒引起的--其中许多病毒在进入人类人口之前从未见过。最近在西非爆发的埃博拉病毒对社会造成的破坏程度，只是表明了这些病毒的潜在影响：如果一种死亡率相近的新出现病毒的传播能力略有增加，其破坏性就会大得多。接种疫苗是控制EID的一种经济有效的方法。然而，这些病毒大多出现在较贫穷的低收入国家，在这些国家，疫苗生产成本高昂，无法在没有外国干预的情况下广泛接种疫苗。高收入国家的疫苗采购严重阻碍了当地人口广泛采用疫苗接种，也破坏了增强中低收入国家永久解决其自身社会和医疗保健问题的能力。当前提案的目的是开发一种适合开发的疫苗平台，以针对低收入国家的新出现病毒。该疫苗平台价格低廉、制造简单、快速，只需一剂或几剂即可提供持久有效的保护性免疫，安全性高，适用于针对多种不同病毒的广泛应用。

Emerging infectious diseases (EIDs) with a potential for substantial and wide spread human mortality are an increasing threat to global stability. EIDs of global significance are most commonly caused by viruses - many of which have never been seen prior to their emergence into the human population. The level of societal disruption associated with the recent Ebola virus outbreak in West Africa gives only an indication of the potential impact of these viruses: only a slight increase in the capacity of an emerging virus with a similar mortality rate to spread will be far more devastating. Vaccination is a cost-effective method of EID control. However, most of these viruses emerge in poorer, low income countries where cost of vaccine production is prohibitive to widespread vaccination without foreign intervention. High-income country vaccine sourcing is a serious impediment to widespread adoption of vaccination by the local population, and also undermines the empowerment of middle/low income countries to permanently resolve their own societal and healthcare problems. The aim of the current proposal is to develop a vaccine platform that is suitable for development to target emerging viruses in low income countries. This vaccine platform will be inexpensive, easy and quick to manufacture, provide long-lasting and effective protective immunity after only a single or few doses, have a high safety profile, and be suitable for broad application against multiple different viruses.