NEUROAIDS/ABUSED DRUGS--ENHANCEMENT OF COGNITIVE BATTERY

这里描述的项目的总体目标是开发一种恒河猴 NeuroAIDS或MDMA诱导的认知效应的猴模型 神经毒性 新艾滋病是艾滋病的重要并发症， 到30%有症状的患者，而大约5-15%的艾滋病患者 弗兰克痴呆症。 神经艾滋病的认知和精神障碍 大大降低了受影响的个人的生活质量及其 关系 摇头丸是一种滥用药物， 神经毒性潜力，但MDMA诱导的行为影响 神经毒性有待证实。 行为电池是由 博士金被用于研究恒河猴模型中的两种topis。 该电池目前由六个任务组成， 认知功能由不同的大脑区域调节。 一个新的任务， 视觉空间配对联想学习任务，将补充 目前试验的区域敏感性， 其他脑区的功能障碍。 任务建议的目标是1） 为了在恒河猴身上开发这种人类神经心理学任务， 2)为电池开发额外的测试措施，以提高其 敏感性，而无需额外的动物训练，以及3）使用这些 表征NeuroAIDS或MDMA诱导的认知的增强 神经毒性

The overall goals of the projects described here are to develop a rhesus monkey model for the cognitive effects of NeuroAIDS or MDMA-induces neurotoxicity. NueoAIDS is significant complication od Aids, affecting up to 30% symptomatic patients, while about 5-15% of those with AIDS develop frank dementia. The cognitive and psychomotor disturbances of NeuroAIDS greatly reduce the quality of life of affected individuals and their relations. "Ecstasy," or MDMA is an abused drug with demonstrated neurotoxic potential, but the behavioral effects MDMA-induced neurotoxicity remain to be shown. The behavioral battery developed by Dr. Gold is being used to study both of the topis in rhesus monkey models. The battery presently consists of six tasks which probe aspects of cognitive function mediated by different brain regions. A new task, visuo-spatial paired-associates learning task, will complement the regional sensitivity of the current tests by being sensitive to dysfunction in additional brain areas. The goals of task proposal are 1) to develop this human neuropsychological task for use in rhesus monkeys, 2) to develop additional testing measures for the battery to enhance its sensitivity without additional animal training, and 3) to use these enhancement to characterize cognitive of NeuroAIDS or MDMA-induced neurotoxicity.