TRAINING GRANT IN MECHANISMS OF VASCULAR DISEASE

血管疾病机制培训计划的更新将把范德比尔特大学和梅哈里医学院血管生物学多部门研究的相当大的优势和多样性集中到一个连贯的专门培训框架中。参与部门包括生物化学，生物医学工程，细胞生物学，微生物学和免疫学，分子生理学和生物物理学，病理学，药理学，化学和两个临床部门（医学和儿科）在范德比尔特，和微生物学在Meharry。培训将在七个专业研究领域提供：（1）蛋白质化学和酶学;（2）生长因子调节/发育;（3）细胞外基质生物学;（4）内皮细胞生物学;（5）脂蛋白代谢和动脉粥样硬化;（6）心血管调节;（7）白细胞/红细胞生物学。每个项目将由4-7名积极从事血管生物学相关方面研究的研究人员组成。该计划将支持8名博士前，6名博士后（医学博士）的津贴。和/或博士）。博士前培训将导致在基础科学学科之一的学位，并将通过研究生招生的中央计划和核心课程，目前在医学院与分子生物学系的参与增强。论文研究将在与血管生物学相关的专业领域之一与该计划的教师之一骨。博士后培训将主要包括在导师指导下的实验室研究。博士前和博士后学员都将被要求参加课程，血管疾病的细胞和分子基础，由参与教师讲授，以及其他课程，取决于候选人的背景。学员还将出席和参加血管生物学和工作进展研讨会和选定的部门研究研讨会。有医学博士学位的学员学位可以寻求博士学位。基础科学学科的学位。希望将来能从事血管生物学领域的教学和科研工作。培训设施包括范德比尔特的5栋相邻的研究大楼和Meharry的微生物学系，这些大楼是导师的研究实验室。参与教师的实验室有充足的空间和最先进的仪器。在这一领域对未来的研究科学家进行多学科研究培训，预计对发现新信息至关重要，这些信息将有助于改善心血管疾病的诊断、预防和治疗。

The renewal of the Training Program in Mechanisms of Vascular Disease will focus the considerable strengths and diversity of multi- departmental research in vascular biology at Vanderbilt University and Meharry Medical College into a coherent framework for specialized training. Participating departments include Biochemistry, Biomedical Engineering, Cell Biology, Microbiology & Immunology, Molecular Physiology & Biophysics, Pathology, Pharmacology, Chemistry and two clinical departments (Medicine and Pediatrics) at Vanderbilt, and Microbiology at Meharry. Training will be offered in seven specialized areas of research: (1) Protein chemistry and enzymology; (2) Growth factor regulation/development; (3) Biology of the extracellular matrix; (4) Endothelial cell biology; (5) Lipoprotein metabolism and atherosclerosis; (6) Cardiovascular regulation, and (7) Leukocyte/red cell biology. Each program will be composed of 4-7 investigators actively pursuing research on related aspects of vascular biology. The program will support stipends for 8 predoctoral, 6 postdoctoral (M.D. and/or Ph.D.). Predoctoral training will lead to a degree in one of the basic science disciplines and will be enhanced by the central program for graduate student recruitment and the core curriculum currently in effect in the School of Medicine with participation by the Department of Molecular Biology. Thesis research will bone in one of the specialized areas related to vascular biology with one of the faculty of this program. Postdoctoral training will consist primarily of laboratory research under the guidance of a faculty supervisor. Both predoctoral and postdoctoral trainees will be required to participate in the course, Cellular and Molecular Basis of Vascular Disease, taught by the participating faculty, and other courses depending on the background of the candidate. Trainees will also attend and participate in the Vascular Biology and Work-in-Progress Seminars and selected departmental research seminars. Trainees with an M.D. degree may seek a Ph.D. degree in one of the basic science disciplines. It is expected that the trainee will the future pursue teaching and research careers in some area of vascular biology. Training facilities include 5 adjacent research buildings at Vanderbilt and the Department of Microbiology at Meharry which house the research laboratories of the preceptors. Ample space and state-of-the- art instrumentation are available in the laboratories of the participating faculty. Multi-disciplinary research training of future research scientists in this area is expected to be critical to discovering the new information that will lead to improved diagnosis, prevention and therapy for cardiovascular diseases.