Biological Mechanisms of Healthy Aging Training Grant

项目摘要/摘要 在过去的二十年里，在理解生物衰老的基本机制方面取得了重大进展。 与此同时，人们迅速认识到这些机制在#年的重要性。 人类健康与疾病，这一概念已被定义为“老年科学”。这一术语指的是 寻求了解衰老和疾病之间这种基本关系的研究方法。使用 这一领域的知识和兴趣迅速扩大，有一个巨大的，未得到满足的需求，以培训下一个 在生物衰老的基本机制和临床的交界处产生科学领袖 相关的年龄相关疾病。这是我们建议的培训计划的基本指导主题 华盛顿大学。我们的使命是提供关于健康的生物机制的前沿培训 衰老。该培训计划将寻求通过在大学提供优秀的受训人员来实现这一目标 华盛顿大学，(1)严格的尖端研究培训，重点是健康的生物机制 老化，(2)接触到知识、概念和知识的广度并进行批判性评估的能力 在实地很重要的方法，以及(3)获得职业成功所必需的指导和技能 并成为未来的科学领袖。该项目将支持6名博士后和6名博士后实习生。我们的 博士后和博士后培训计划为我们提供了一个丰富的环境，使我们能够在 我们的教员和我们的参与部门和项目具有相当大的优势。这包括老化- 相关课程、期刊俱乐部、实习生研究报告、系列研讨会和对出席 以老龄化为重点的全国性会议。我们通过通常为3-4(Pre-4)提供支持来提供培训连续性 博士)或2-3年(博士后)。博士前候选人通常在研究生二年级接近尾声时开始 培训和博士后在他们的研究生培训的第一年。该计划的实习生将成为熟练的 并有动力努力增加对负责的潜在机制的了解 导致衰老中疾病负担的过程，以及有助于发现新的 采取干预措施，防止或扭转这种情况。

Project Summary/Abstract The past two decades have seen major advances in understanding the basic mechanisms of biological aging. Simultaneously, there has been a rapidly growing appreciation of the importance of these mechanisms in human health and disease, which has been conceptualized by the term “geroscience”. This term refers to the research approach that seeks to understand this fundamental relationship between aging and disease. With the rapid expansion in knowledge and interest in this field, there is a great, unmet need to train the next generation of scientific leaders at the interface of fundamental mechanisms of biological aging and clinically relevant age-related disease. This is the underlying, guiding theme of our proposed training program at the University of Washington. Our mission is to provide cutting-edge Training in Biological Mechanisms of Healthy Aging. This training program will seek to achieve this goal by providing outstanding trainees at the University of Washington with (1) rigorous training in cutting edge research focused on biological mechanisms of healthy aging, (2) exposure to, and the ability to critically evaluate, the breadth of knowledge, concepts, and approaches important in the field, and (3) the mentoring and skill sets necessary to achieve career success and become future scientific leaders. The program will support 6 pre- and 6 post-doctoral trainees. Our training program for both pre-and post-doctorates provides a rich environment in which we build upon the considerable strengths of our Faculty and our participating Departments and Programs. This includes aging- related courses, journal club, trainee research presentations, seminar series and support for attendance at national aging-focused meetings. We provide continuity of training by typically providing support for 3-4 (pre- doc) or 2-3 (post-doc) years. Predoctoral candidates ordinarily begin near the end of their 2nd year of graduate training and post-docs in their 1st year of post-graduate training. Trainees from this program will become skilled and motivated to work to increase the understanding of the underlying mechanisms responsible for the processes that contribute to the burden of disease in aging, as well as contributing to the discovery of new interventions to prevent or reverse them.