Biological Mechanisms of Healthy Aging Training Grant

健康老龄化的生物机制培训补助金

• 批准号: 10407664
• 负责人: Daniel Edward Promislow
• 金额: $ 77.6万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10407664
• 关键词: Biological; Grant; Training; healthy aging

Project Summary/Abstract The past two decades have seen major advances in understanding the basic mechanisms of biological aging. Simultaneously, there has been a rapidly growing appreciation of the importance of these mechanisms in human health and disease, which has been conceptualized by the term “geroscience”. This term refers to the research approach that seeks to understand this fundamental relationship between aging and disease. With the rapid expansion in knowledge and interest in this field, there is a great, unmet need to train the next generation of scientific leaders at the interface of fundamental mechanisms of biological aging and clinically relevant age-related disease. This is the underlying, guiding theme of our proposed training program at the University of Washington. Our mission is to provide cutting-edge Training in Biological Mechanisms of Healthy Aging. This training program will seek to achieve this goal by providing outstanding trainees at the University of Washington with (1) rigorous training in cutting edge research focused on biological mechanisms of healthy aging, (2) exposure to, and the ability to critically evaluate, the breadth of knowledge, concepts, and approaches important in the field, and (3) the mentoring and skill sets necessary to achieve career success and become future scientific leaders. The program will support 6 pre- and 6 post-doctoral trainees. Our training program for both pre-and post-doctorates provides a rich environment in which we build upon the considerable strengths of our Faculty and our participating Departments and Programs. This includes aging- related courses, journal club, trainee research presentations, seminar series and support for attendance at national aging-focused meetings. We provide continuity of training by typically providing support for 3-4 (pre- doc) or 2-3 (post-doc) years. Predoctoral candidates ordinarily begin near the end of their 2nd year of graduate training and post-docs in their 1st year of post-graduate training. Trainees from this program will become skilled and motivated to work to increase the understanding of the underlying mechanisms responsible for the processes that contribute to the burden of disease in aging, as well as contributing to the discovery of new interventions to prevent or reverse them.

项目总结/摘要 在过去的二十年里，人们在理解生物衰老的基本机制方面取得了重大进展。 与此同时，人们也迅速认识到这些机制在以下方面的重要性： 人类健康和疾病，这已被概念化的术语“老年科学”。这个词指的是 这是一种旨在了解衰老和疾病之间基本关系的研究方法。与 随着这一领域的知识和兴趣的迅速扩大，对下一个领域的培训有着巨大的、未满足的需求。 在生物衰老和临床基本机制的界面上产生科学领导者 与年龄有关的疾病。这是我们在2010年提出的培训计划的基本指导主题。 华盛顿大学。我们的使命是提供健康的生物机制的尖端培训 衰老这个培训计划将寻求通过提供优秀的学员在大学实现这一目标 华盛顿的一位高级研究员，他（1）在尖端研究方面受过严格的训练，重点是健康的生物机制， 老化，（2）接触，并有能力批判性地评估，知识的广度，概念， 该领域重要的方法，以及（3）实现职业成功所需的指导和技能 成为未来的科学领导者。该计划将支持6名博士前和6名博士后学员。我们 为前和博士后培训计划提供了一个丰富的环境，我们建立在 我们的教师和我们的参与部门和计划的相当大的优势。包括老化- 相关课程、期刊俱乐部、受训人员研究报告、系列研讨会和对出席 以老龄问题为重点的国家会议。我们提供培训的连续性，通常提供支持3-4（预 2-3年（post-doc）博士预科生通常开始接近他们的研究生第二年年底 培训和博士后研究生培训的第一年。该计划的学员将成为熟练的 并有动力努力提高对造成这些问题的根本机制的认识， 这些过程有助于衰老中的疾病负担，以及有助于发现新的 采取干预措施，以防止或扭转这些情况。