An integrated molecular approach to human gene regulation

本研究旨在揭示细胞核RNA和蛋白分子的相互作用如何在细胞应激条件下控制基因调控。为了理解遗传变异如何导致基因表达的变化，我们需要对支撑复杂基因调控系统的基本原理有新的认识。建立在发现副斑，新的基因调控结构的基础上，该项目将产生对基因调控的见解，这将有助于填补这些知识空白。这将为RNA介导的基因调控提供更全面的理解，并将为靶向RNA基因调控复合物的研究开辟新的机会。

This proposal aims to reveal how the interaction of nuclear RNA and protein molecules control gene regulation in the face of cell stress. To understand how genetic variation leads to changes in the expression of genes, we need new insights into the fundamental principles underpinning complex gene regulatory systems. Building on the discovery of paraspeckles, novel gene regulatory structures, this project will yield insights into gene regulation that will help fill these knowledge gaps. This will provide a more comprehensive understanding of RNA-mediated gene regulation, and will open up new research opportunities to target RNA based gene regulatory complexes.