FMRI INVESTIGATIONS OF THE PARAHIPPOCAMPAL PLACE AREA

所有航行的生物体都必须回答一个基本问题，即 我现在是吗？在过去的8个月里，我实验室的功能核磁共振研究 确定了皮层的一个区域，我们称之为海马旁区域 (购买力平价)，这似乎在解决这一问题方面发挥了核心作用。 我们已经对30名受试者中的28名进行了功能性定位 测试表明，PPA在高度选择性的情况下 时尚对描绘场所的视觉刺激，当 受试者观看室内和室外场景的照片，但只有非常 对常见物体和人脸的照片表现出较弱的视觉效果。的目标是 拟议的研究是为了明确PPA的确切功能 相关的神经结构(例如，海马体、大脑周围和 内嗅皮层和顶区)在位置知觉中， 导航和空间认知。第一部分的实验奠定了 为未来的研究奠定基础，通过表征解剖学和 详细介绍了PPA及其相关结构的功能性质。 第二部分中的实验旨在准确地描述 驱动PPA的各种刺激。在明确定义了 激活PPA的刺激类别，第三部分将确定 PPA及其相关神经结构加工的本质 执行这些刺激。具体地说，这些实验测试了 人民党和其他地区在一)知觉方面的参与 刺激分析(知觉假说)，II) 将该感知信息与存储的 地点的外观(认知假说)，三) 将知觉信息编码到记忆中(记忆 编码假设)，和/或iv)确定如何从 当前位置到认知地图中的某个其他已知位置， 即路线规划(路线规划假说)

All navigating organisms must answer the fundamental question, where am I now? FMRI research in my lab over the last 8 months has identified a region of cortex we call the parahippocampal place area (PPA), which appears to play a central role in solving that problem. We have functionally localized the PPA in 28 out of 30 subjects tested and have shown that the PPA responds in a highly selective fashion to visual stimuli depicting places, responding robustly when subjects view photographs of indoor and outdoor scenes, yet only very weakly to photographs of common objects and faces. The goal of the proposed research is to specify the precise function of the PPA associated neural structures (e.g., the hippocampus, perirhinal and entohinal cortex, and parietal regions) in place perception, navigation, and spatial cognition. The experiments in Part I lay the groundwork for future studies by characterizing the anatomical and functional properties of the PPA and associated structures in detail. The experiments in Part II are designed to precisely characterize the kinds of stimuli that drive the PPA. Having clearly defined the categories of stimuli that activate the PPA, Part III will determine the nature of the processing the PPA and associated neural structures carry out on those stimuli. Specifically, these experiments test the involvement of the PPA and other regions in I) the perceptual analysis of the stimulus (the Perception Hypothesis), ii) the comparing of that perceptual information to stored representations of the appearances of places (the Recognition Hypothesis), iii) the encoding of theat perceptual information into memory (the Memory Encoding Hypothesis), and/or iv) determining how to get from the current location to some other known location in the cognitive map, i.e. route planning (the Route-Planning Hypothesis)