Unveiling the epigenome dynamics through the pluripotency continuum

该项目旨在利用基于干细胞和基因组学的技术，结合新的计算算法来剖析在开发过程中驱动第一步的基本分子事件。预计该项目将揭示驱动发育总体计划的基因如何在细胞中受到控制的基本机制，这些细胞具有形成整个有机体和胎盘的能力。从这项工作中获得的知识将为未来的新方法提供信息和指导，例如在辅助生殖技术或再生医学方面。

This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The knowledge gained from this work will inform and guide future novel approaches, such as in assisted reproductive technologies or regenerative medicine.