RETENTION OF BONE MARROW DONORS IN A NATIONAL REGISTRY

描述：随着骨髓移植成为首选的 治疗危及生命的血液疾病，越来越多的 病人必须从无关的捐赠者那里寻找相容的骨髓。 低 找到良好的患者-供体骨髓匹配的概率意味着 三分之一到三分之二的病人从来没有找到一个完美的捐赠者。 相容的骨髓 此外，一旦志愿者被确定为 初步匹配的病人，30%至40%要么不愿意， 从医学角度来说无法捐献骨髓 因此，志愿者流失 在很大程度上加剧了在寻找一个 合适的捐赠者候选人 尽管维护大量不相关的登记册至关重要 志愿捐献者候选人，没有系统的研究影响因素， 成功地留住了这些志愿人员。 拟议的研究是 旨在确定影响国家骨髓捐献者计划的因素， （NMDP）成功保留骨髓志愿者。 这尤其 这项研究将探讨志愿者特征和捐赠者之间的关系。 中心因素志愿者心理结果在两个关键 血液检测过程中的各个阶段以及到献血中心的志愿者比率 在这些阶段的合作。 纵向和横截面调查数据将从一个总的 2,600名潜在的骨髓捐献者，他们正处于两个关键决定之一， 献血过程中的各个点（DR血型定型， CT血型），并从100个NMDP供体中心的工作人员。 这些 数据将使研究人员能够（a）描述分布情况， 供体中心结构特征与 中心用于志愿者招募和保留的策略，（B） 确定哪些捐助中心因素（结构和战术）， 志愿者背景特征最能预测阳性 在后期打字阶段的志愿者特定心理结果，以及 审查和修订个别志愿人员具体成果的模式， 汇总跨中心保留率。 研究结果将更好地促进 了解捐助者管理的组织特点， 是成功保留骨髓志愿者的关键，请告知 修订医疗志愿服务的概念模型，并指导未来 努力在活体器官捐赠的各个方面争取捐赠者。

DESCRIPTION: As bone marrow transplantation becomes one of the preferred treatments for life-threatening diseases of the blood, increasing numbers of patients must seek compatible marrow from unrelated donors. The low probability of finding a good patient-donor marrow match means that between one- to two-thirds of ill patients never locate a donor with perfectly compatible marrow. Furthermore, once volunteers are identified as a preliminary match for a patient, 30 to 40 percent are either unwilling or medically unable to actually donate marrow. Thus, volunteer attrition contributes significantly to the problems already inherent in finding a suitable donor candidate. Despite the critical importance of maintaining a large registry of unrelated volunteer donor candidates, no systematic studies of factors affecting the successful retention of such volunteers exists. The study proposed is designed to identify factors that affect the National Marrow Donor Program's (NMDP) success in retention of bone marrow volunteers. In particular, this study will examine the relationship of volunteer characteristics and donor center factors to volunteer psychological outcomes during two critical stages in the blood testing process and to donor center rates of volunteer cooperation at these stages. Longitudinal and cross-sectional survey data will be gathered from a total of 2,600 potential marrow donors who are at one of two critical decision points in the process leading to donation (DR-blood-typing, CT-blood-typing), and from personnel at the 100 NMDP donor centers. These data will allow the investigators to (a) describe the distribution and interrelationships between donor center structural characteristics and the strategies centers utilize for volunteer recruitment and retention, (b) determine which donor center factors (both structural and tactical) and volunteer background characteristics best predict positive volunteer-specific psychological outcomes at later typing stages, and examine and revise models of individual volunteer-specific outcomes and aggregate across-center retention rates. Study findings will promote better understanding of the donor management organizational characteristics that are central to successful retention of marrow volunteers, inform the revision of conceptual models of medical volunteerism, and guide future efforts to secure donors across the full range of living-organ donation.