OUTCOME OF ATTENTION DEFICIT HYPERACTIVITY DISORDER

描述：这项建议计划跟踪117名青少年 与ADHD患者和100多名患者的可比对照组 兄弟姐妹，受试者已经跟踪了五年，另外五年 好几年了。鉴于样本的平均年龄，这项研究将提供 关于受试者从青春期到青春期的ADHD信息 生活。这些科目将在六个领域进行评估：精神病理学， 认知-神经心理功能、学校功能障碍、适应性 功能、治疗干预和心理社会逆境。品种繁多 在每个领域的评估中都包括了一系列的措施。分析方法 解决六个问题：精神疾病的发病年龄可变； 家庭内部和时间段之间的观察不独立； 治疗效果；整合多个告密者的信息； 混杂变量的影响；基线时样本的广泛年龄范围。 研究人员将检验三个普遍的假设：结果预测 根据基线ADHD(或ADHD的兄弟姐妹)；基于以下因素预测结果 共病；根据DSM-IV亚型预测结果和共病。

DESCRIPTION: This proposal intends to follow a group of 117 adolescents with ADHD and a comparable control group for as well as over 100 of their siblings, subjects already followed for five years, for an additional five years. Given the mean age of the sample, this study will provide information about ADHD as subjects mature from adolescence into young adult life. These subjects will be assessed on six domains: psychopathology, cognitive-neuropsychological functioning, school dysfunction, adaptive functioning, treatment interventions and psychosocial adversity. A variety of measures are included in the assessment of each domain. Analytic methods address six issues: variable age of onset of psychiatric illness; nonindependence of observations within families and between time periods; effects of treatment; integration of information across multiple informants; effects of confounding variables; wide age range of the sample at baseline. The investigators will test three general hypotheses: prediction of outcome based on baseline ADHD (or sibling of ADHD); prediction of outcome based on comorbidity; prediction of outcome and comorbidity based on DSM-IV subtypes.