TGF-B RECEPTOR ALTERATIONS AND PANCREAS CANCER

描述：这项研究的长期目标是确定 转化生长因子β受体(RII)在胰腺癌中的表达对以下事件失去响应 转化生长因子β似乎常见于胰腺癌，这通常是由缺失引起的。 RII基因的表达。将在本修订版中检验的假设 应用是ras介导的RII基因表达缺失 基因的下调和功能RII受体的缺乏发挥了作用 在胰腺癌的致癌特性中起着重要作用。这个 具体目标是：1)确定致癌ras抑制的机制。 RII表达和/或引起对转化生长因子β抑制生长的抵抗，以及 2)确定RII在ras突变的肿瘤进展中的生物学作用 胰腺癌细胞。

DESCRIPTION: The long term goal of this study is to determine the role of TGFbeta RII receptor (RII) in pancreatic cancer. Loss of response to TGFbeta appears common to pancreatic cancer, which is often caused by a loss of the RII gene expression. The hypothesis to be tested in this revised application is that the loss of RII expression is caused by ras-mediated down regulation of the gene and that lack of a functional RII receptor plays an important role in the tumorigenic properties of pancreatic cancers. The specific aims are 1) Determine the mechanism by which oncogenic ras inhibits RII expression and/or causes resistance to growth inhibition by TGFbeta, and 2) Determine the biological role of RII in tumor progression in ras-mutated pancreatic cancer cells.